Alan S. Mak, Ph.D

Alan S. Mak
  • Emeritus Professor
  • Kingston
  • K7L3N6
  • Telephone: 613-533-2989
  • E-Mail: maka@queensu.ca

Faculty Bio

We are interested in the mechanisms by which vascular smooth muscle cells migration is inhibited in healthy arteries, but stimulated under pathological conditions. Specifically, we study the roles of an organelle called podosome that is known to play a critical role in cell movement and invasion. Before a cell can move out of its normal habitat in the blood vessel, it needs to develop feet-like podosomes to allow it to crawl. Thus, development of podosome is the first step for a smooth muscle cell to invade its surrounding by excavating a 'tunnel' into which it can move. In our studies, we employ a combination of biochemical, biophysical, cell imaging, and molecular biology techniques.

Last Modified: 2016-11-10