Research Interests:

The focus of my Neuroscience research program is directed toward understanding how central autonomic control centres maintain many critical variables (glucose, oxygen, blood pressure, sodium, potassium, calcium ....) within the finely controlled limits that are essential to normal physiological function and thus “optimal health.” In particular we are interested in the circuitry and the diverse chemical transmitters which make these physiological systems work. We have approached this problem using multidisciplinary approaches and a variety of different tools as illustrated below:

These studies are designed ultimately to provide targets for potentially understanding changes which may take place in the brain and contribute to the development of autonomic disease states such as hypertension and obesity. Our studies have contributed to a growing literature emphasizing the integration and overlap of separate autonomic systems (cardiovascular, respiratory, gastrointestinal, immune, metabolic....) within the same autonomic control centers in the CNS.