Edmond Chan, Ph.D.
Room 627 Botterell Hall
Tel: 613 533 6946
Autophagy as a metabolic homeostasis mechanism
The metabolic status of a cell guides critical decisions such as growth, death or differentiation. We aim to understand the fundamental signalling mechanisms that allow mammalian cells to adapt following external stress, focussing on the autophagy pathway.
Autophagy is the main route for channelling cellular material to the lysosome for degradation and internal recycling. By this route, autophagy serves a critical role for maintaining metabolic homeostasis and we are interested in 2 particular contexts: normal cellular aging and cancer cell survival. Cancer cells are distinct for their re-programmed metabolic profile that features high catabolism of glucose and amino acids. Therefore, we have long been interested in the mechanisms linking these cellular nutrients to autophagy in normal and cancer cells.
Assistant Professor, Adjunct, Queen’s University Department of Biomedical and Molecular Sciences, Department of Pathology and Molecular Medicine (2018).
Lecturer, Strathclyde Institute of Pharmacy and Biomolecular Sciences. University of Strathclyde, Glasgow, UK (2008-2018).
Post Doctoral Research Associate, Cancer Research UK London Research Institute (2003-2008).
Post Doctoral Research Associate, Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia (1999-2003).
Ph.D. Department of Biochemistry, University of Alberta (1994-1999).
Last Modified: 2018-11-01