Dr. Tayade’s research is focused on understanding the pathophyisology of endometriosis. The unifying theme of his research program is to determine how neo-angiogenesis is regulated by endothelial and hematopoietic progenitor cells and to elucidate the mechanisms by which these cell types could be therapeutically manipulated in physiological processes such as pregnancy and in pathological conditions such as endometriosis. Specifically he is interested in defining the association of immune mechanisms with neoangiogenesis and survival of endometriotic lesions. His laboratory is investigating specific mechanisms supporting blood vessel growth in endometriosis that can be safely targeted using anti-angiogenic therapies. He has established a new mouse xenogeneic engraftment model and currently validating the efficacy of several anti-angiogenic compounds. His laboratory uses a combination of molecular biology approaches, patient-based studies and immunodeficient mouse models. Dr. Tayade is recipient of J. Christian Herr Award from the American Society for Reproductive Immunology for outstanding research contribution.
Sources of Research Funds:
Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council, Canada Foundation for Innovation, and Industrial Awards from Bayer Pharmaceuticals and Primus Pharmaceuticals,