Research Interests:Our current research interest is the regulatory role of glycoproteins secreted by the oviduct in sperm-egg interaction and reproductive functions. Our research focuses on the study of how the postovulatory environment in the oviduct influences gamete maturation, fertilization, and preimplantation development. We are also interested in the structure-function relationship between oviductal secretions and other ovary-specific glycoproteins that make up the zona pellucida of postovulatory oocytes. We have recently produced a human recombinant oviduct-specific glycoprotein (oviductin). We are particularly interested in studying the role of human oviductin in stimulating the increase in tyrosine phosphorylation of sperm proteins during capacitation and in the enhancement of sperm-egg binding with the hope of defining sperm quality and fertilizing competence for proper and ethical use of assisted reproductive technology (ART) in alleviating male infertility. Another project being undertaken in our laboratory involves the use of low-dose immunosuppressant therapy and the study of its underlying mechanisms in ameliorating and restoring normal reproductive functions in subjects with diabetes.
Sources of Research Funds: Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Kingston General Hospital Medical Research Fund