Selected Publications:

(*)  indicates graduate student and/or research trainee in my laboratory

*Zhao, Y and F.W.K. Kan (2019) Human OVGP1 enhances tyrosine phosphorylation of sperm proteins in the fibrous sheath involving AKAP3 and increases sperm-egg binding. Journal of Assisted Reproduction and Genetics 36:1367-1377.         

Albaghdadi, A.J.H., *C.A. Feeley, F.W.K. Kan (2019) Low-dose tacrolimus prevents dysregulated peri-conceptional ovarian and systemic immune cellular homeostasis in subjects with PCOS. Scientific Reports. 2019 April 25; 9(1):6528. doi:10.1038/s41598-019-42960-x.

*Albaghdadi, A.J.H. and F.W.K. Kan. (2018) Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: Comparative studies with metformin. Molecular and Cellular Endocrinology. 2018 Jan. 15; 460:73-84. doi:1016/j.mce.2017.07.007. Epub 2017 Jul 8. PMID:28689771. 

*Albaghdadi, A.J.H., *M.A. Hewitt, S.M. Putos, M. Wells, T.R.S. Ozolins, F.W.K. Kan. (2017) Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice. Journal of Translational Medicine. Feb. 13; 15(1):32. dot:10.1186/s12967-017-1137-4.

Bidarimath M., K. Khalaj K., R.T. Kridli, F.W.K. Kan, M. Koti, C. Tayade. (2017) Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk. Scientific Reports Jan 12; 7:40476. doi:10.1038/srep40476.

*Shorter, S.L., *A.J. Albaghdadi, F.W.K. Kan. (2016) Alterations in oviductal cilia morphology and reduced expression of axonemal dynein in diabetic NOD mice. Tissue and Cell. 48(6): 588-596. doi:10.1016/j.tice.2016.10.003.

*Zhao, Y., *X. Yang, Z. Jia, R. L. Reid, P. Leclerc, F.W.K. Kan. (2016) Recombinant human oviductin regulates tyrosine phosphorylation and acrosome reaction. Reproduction. 152(5): 561-573.

*Yang, X., *Y. Zhao, X. Yang, F.W.K. Kan. (2015) Recombinant hamster oviductin is biologically active and exterts positive effects on sperm functions and sperm-oocyte binding. PLos One. April 7; 10(4):e0123003. doi: 10.1371/journal.pone.0123003. eCollection 2015.

Kan, F.W.K. (2014) Freeze-fracture immunocytochemistry: fracture-label and label-frafture for the localization of membrane proteins. Current Protocol in Cell Biology.  Dec 1; 65:4.28.1-2.28.15. doi:10.1002/0471143030.cb0428s65

*Khosravi, F., R.L. Reid, A. Moini, F. Abolhassani, F.W.K. Kan. (2013) In vitro development of human primary follicles to preantral stage after vitrification. J. Assist. Reprod. Genet. 30:1397-1406

*Saccary, L., Y.M. She, R. Oko, F.W.K. Kan (2013) Hamster oviductin regulates tyrosine phosphorylation of sperm proteins during in vitro capacitation. Biology of Reproduction Aug 22; 89(2):38. doi: 10.1095/biolreprod.113.109314. Print 2013 Aug. 

*Yang, X., S. Tao, R. Orlando, I. Brockhausen, F.W.K. Kan. (2012) Structures and biosynthesis of the N- and O-glycans of recombinant human oviduct-specific glycoprotein expressed in human embryonic kidney cells.  Carbohydrates Research 358:47-55

*Albaghdadi, A. and F.W.K. Kan. (2012) Endometrial receptivity defects and impaired implantation in diabetic NOD mice.   Biology of Reproduction Aug 2; 87(2):30. doi: 10.1095/bioreprod.112.100016. Print 2012 Aug.

Wu, Z., F.W.K. Kan, Y.-M. She, V.K. Walker. (2012)  Biofilm, ice recrystallization inhibition and freeze-thaw protection in an epipihyte community. Applied Biochemistry and Microbiology 48:403-410

Yan, J., J. Suzuki, X.-M. Yu, J. Qiao, F.W.K. Kan, R.C. Chian. (2011) Effects of duration of cryo-storage of mouse oocytes on cryo-survival, fertilization and embryonic development following vitrification.  Journal of Assisted Reproduction and Genetics 28:643-649

Yan, J., J. Suzuki, X.-M. Yu, F.W.K. Kan, J. Qiao, R.C. Chian. (2010) Cryo-survival, fertilization and early embryonic development of vitrified oocytes derived from mice of different reproductive age. Journal of Assisted Reproduction and Genetics  27:605-611.

Moos, M.P.W., J.D. Mewbiurn, F.W.K. Kan, S. Ishii, M. Abe, K. Sakimura, K. Noguchi, T. Shimizu, C.D. Funk.  (2008)  Cysteinyl leukotriene 2 receptor mediated vascular permeability via transendothelial vesicle transport.  FASEB Journal 172: 592-602

Kan, F.W.K., P.-K. Forkert, M. Wade. (2007) Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice. Histology and Histopathology  22: 977-988

Kan, F.W.K.  (2006) Molecular dissection of the mouse zona pellucida: An electron microscopic perspective utilizing colloidal-gold labeling methods. Methods in Molecular Biology, Vol.347: Glycobiology Protocols, Edited by Inka Brockhausen, Chapter 19, Humana Press Inc., Totowa, New Jersey, p.289-304

Kan, F.W.K. and *P.W.B. Esperanzate.  (2006) Surface mapping of binding of oviductin to the plasma membrane of golden hamster spermatozoa during in vivo capacitation and acrosome reaction.  Molecular Reproduction and Development 73: 756-766

Kan, F.W.K. and *D.S. McBride. (2005) Estrous Cycle-dependent glycosylation and post-translational modification of oviductin in the golden hamster (Mesocricetus auratus). In: New Impact in protein modifications in the regulation of reproduction.Toshinobu Tokumoto, Editor, Chapter 8, Research Signpost, Kerala, India, p.135-153

 *Ling, L., Y.L. Lee, K.F. Lee, S.W. Tsao, W.S.B. Yeung, F.W.K. Kan,  (2005)  Human oviductin mRNA is expressed in an immortalized human oviductal cell line.  Sterility and Fertility 84: 1095-1103

*McBride, D.S., I. Brockhausen, F.W.K. Kan,  (2005) Detection of glycosyltransferases in the Golden Hamster (Mesocricetus auratus)  oviductin and evidence for the regulation of O-glycan biosynthesis during the estrous cycle. Biochimica et Biophysica Acta 1721: 107-115

*McBride, D.S., C. Boisvert, G. Bleau, F.W.K. Kan. (2004) Detection of nascent and/or mature forms of oviductin in the female reproductive tract and post-ovulatory oocytes by use of a polyclonal antibody against recombinant hamster oviductin.  Journal of Histochemistry & Cytochemistry 52:1001-1009