Colin D. Funk, Ph.D

Colin D. Funk

Faculty Bio

B.Sc. (Queen’s), Ph.D. (McGill)

Research Interests:    Gene editing in urea cycle disorders; Eicosanoid signaling pathways; Free fatty acid receptor 4 (FFAR4) signaling and relationship with omega3 polyunsaturated fatty acids

In general, we study the molecular, cellular, and (patho)physiological contexts of health and disease. We are carrying out new genome editing strategies (TALENs, CRISPRs) using induced pluripotent stem cells derived from patients with urea cycle defects (arginase-1 deficiency) and an inducible knockout strain of mice with the corresponding genetic defect. We also study a group of lipid mediator molecules known as eicosanoids, the enzymes that biosynthesize these products, and the receptors that transduce their effects. We are exploring the roles of cyclo-oxygenase (COX) enzymes in various aspects of the cardiovascular system using unique mouse models achieved through gene-targeting methodology. Research in the Funk Lab also includes the study of omega 3 fatty acids and how they signal through the fatty acid receptor FFAR4 to modulate inflammation, especially within the context of the cardiovascular system.

Last Modified: 2015-09-02