Selected Publications:

  • Selected Reviews
    1. I Brockhausen, J Schutzbach, W Kuhns. Glycoproteins and their relationship to human disease. (1998) Acta Anat. 161: 36-78.
    2. I Brockhausen. Pathways of O-glycan biosynthesis in cancer cells. (1999) Biochim. Biophys. Acta, 1473: 67-95.
    3. I Brockhausen. The role of galactosyltransferases in cell surface functions and in the immune system. (2006) Drug News and Perspectives 19(7): 401-409.
    4. J Schutzbach, H Ankel, I Brockhausen. Synthesis of cell envelope glycoproteins of Cryptococcus laurentii. (2007) Carbohydr. Res.
    5. Glycobiology Protocols in Methods in Molecular Biology. I. Brockhausen Ed. (2006) Humana Press.
    6. I Brockhausen. Biochemical Aspects: Biosynthesis of O-glycans. In Comprehensive Glycosciences, From Chemistry to Systems Biology. (2007) Elsevier.
    7. I Brockhausen. Structure and function of glycosyltransferases specific for O-glycan processing. (2007) In Glycobiology, Scion Publ. Woodbury NY.
    8. J. Schutzbach, I Brockhausen.  Inhibition of glycosyltransferase activities as the basis for drug development.  (2009) Methods in Molecular Biology, Humana Press, Totowa, NY. 534: 1-15.
    9. I Brockhausen. biosynthesis of complex mucin-type O-glycans. (2009) Comprehensive Natural Products Chemistry II Volume 5, Carbohydrates, nucleosides and nucleic acids.  G. Wang Ed. Elsevier.
  • Selected papers
    1. I Brockhausen, J Yang, J Burchell, C Whitehouse, J Taylor-Papadimitriou. Mechanism underlying aberrant glycosylation of the MUC1 mucin in breast cancer cells. (1995) Eur. J. Biochem., 233: 607-617.
    2. C Whitehouse, J Burchell, S Gschmeissner, I Brockhausen, K Lloyd, J Taylor-Papadimitriou. A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core 2-based O-glycans. (1997) J. Cell Biol., 137:1229-1241.
    3. I Brockhausen, J Yang, N Dickinson, S Ogata, S Itzkowitz. Enzymatic basis for sialyl-Tn expression in human colon cancer cells. (1998) Glycoconj. J., 15: 595-603.
    4. I Brockhausen, M Lehotay, J Yang, W Qin, D Young, J Lucien, J Coles, H Paulsen. Glycoprotein biosynthesis in porcine aortic endothelial cells and changes in the apoptotic cell population. (2002) Glycobiology, 12: 33-45.
    5. X Yang, W Qin, M Lehotay, D Toki, P Dennis, J Schutzbach, I Brockhausen. Soluble human core 2 beta6-GlcNAc-transferase requires its conserved Cys residues for full activity (2003) Biochim. Biophys. Acta, 1648:62-74.
    6. X Yang, M Lehotay, T Anastassiades, M Harrison, I Brockhausen. The effect of TNFalpha on glycosylation pathways in bovine synoviocytes. (2004) Biochemistry and Cell Biology, 82(5):559-568.
    7. DS McBride, I Brockhausen. FWK Kan. Detection of glycosyltransferases in the golden hamster (Mesocricetus auratus) oviduct and evidence for the regulation of O-glycan biosynthesis during the estrus cycle. (2005) Biochim. Biophys. Acta, 1721:107-115.
    8. JG. Riley, M Menggad, P Montoya-Peleaz, WA. Szarek, CL Marolda, MA Valvano, JS Schutzbach, I Brockhausen. The wbbD gene of E. coli strain VW187 (O7:K1) encodes a UDP-Gal: GlcNAc(alpha)-pyrophosphate-R (beta)1,3-galactosyltransferase involved in the biosynthesis of O7-specific lipopolysaccharide. (2005) Glycobiology, 15: 605-613.
    9. I Brockhausen, M Benn, S Bhat, S Marone, JG, Riley J, P Montoya-Peleaz, JZ Vlahakis, H Paulsen, JS Schutzbach, W Szarek. UDP-Gal: GlcNAc-R beta1,4-Galactosyltransferase - a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme. (2006) Glycoconj. J., 23: 523-539.
    10. X Yang, J Yip, T Anastassiades, M Harrison, I Brockhausen. The action of TNFalpha and TGFbeta include specific alterations of the glycosylation of bovine and human chondrocytes. (2006) Biochim. Biophys. Acta.
    11. Y Li, X Yang, A Nguyen, I Brockhausen. Requirement of N-glycosylation for the secretion of recombinant extracellular domain of human Fas in heLa cells. (2007) Internat. J. Biochem. Cell Biol. 39: 1625-1636.
    12. X Yang, J Yip, M Harrison, I Brockhausen. Primary human osteoblasts and bone cancer cells as models to study glycodynamics in bone. (2007) Internat. J. Biochem. Cell Biol.
    13. I Brockhausen, J Riley, M Joynt, X Yang, WA Szarek.  Acceptor substrate specificity of UDP-Gal: GlcNAc-R b1,3-galactosyltransferase from Escherichia coli O7:K1.  (2008) glycoconj. J. 25: 663-673.
    14. I Brockhausen, B Liu, B Ju, K Lau, W Szarek, L Wang, L Feng.  Characterization of two UDP-GlcNAcNAc: b1,3-glucosyltranferases from the Escherichia coli serotypes O56 and O152. (2008) J. Bacteriol. 190: 4922-4932.
    15. I Brockhausen, T Dowler, H Paulsen. Site directed processing: Role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2.  (2009)  Biochim. Biophys. Acta, 1790: 1244-1257.
    16. J Riley, C Xu, I Brockhausen. Synthesis of acceptor substrate analogs for the study of glycosyltransferases involved in the second step of the biosynthesis of O antigen repeating units.  (2010) Carbohydr. Res. 2010, DOI: 10.1016/j.carres.2009.12.022