Research Interests:Protein crystallography is a powerful tool capable of revealing atomic details of protein. The technique has been widely used to determine 3-D structures of proteins, multi-domain large protein complexes, protein-DNA interactions etc. Protein crystallography has in the last decade advanced greatly and made a major contribution to the fundamental understanding of biological processes and provided insights into problems of molecular recognition and biological control of importance to medicine and the pharmaceutical industry. Our research, currently focusing on structure-function studies of a number of biologically significant proteins, is largely funded by Canadian Institutes of Health Research (CIHR) and Natural Sciences and Engineering Research Council of Canada (NSERC). Please visit our lab website to find out more.
Phosphatases/kinases are involved in a wide range of cellular processes. We are working on a number of novel bacterial kinases and phosphatase. Along with structural characterization, we are also interested in probing their cellular and biochemical function by using a wide variety of approaches including cell biology, biochemical and biophysical methods.
Bacterial structure genomics provides us with an opportunity to systematically study a selected group of protein. We are particularly interested in proteins with "unknown" function and protein-protein complex structures, as well as those involved in pathogen-host interactions. Based on the structural insights, we hope to obtain important clues for the function, and subsequently verify it by biochemical experiments.