John Allingham, Ph.D

John Allingham
  • Associate Professor and Canada Research Chair in Structural Biology
  • Botterell Hall, Room 650
  • Kingston
  • K7L3N6
  • Telephone: 613-533-3137 x33137
  • E-Mail: allinghj@queensu.ca

Faculty Bio

Education:
B.Sc. (Hons.) in Biochemistry (1996) - The University of Western Ontario

Ph.D. in Biochemistry and Molecular Biology (2002) - The University of Western Ontario
CIHR Postdoctoral Fellow in Structural Biology (2002-2006) - Department of Biochemistry, University of Wisconsin

Current Funding:
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council
Canada Research Chairs Program

Research Interests:   
• Structure-function relationships in kinesin motor proteins
• Roles of kinesins in mitotic spindle function and cell shape changes in human fungal pathogens and cancer cells
• Molecular recognition of protein surfaces and perturbation of protein function by natural toxic small molecules
• Protein engineering and drug design

A primary goal of the research in my lab is to understand the mechanisms of action of biomolecules, and, where possible, to rationally alter or re-purpose their functions in useful ways. To do this, we use X-ray crystallography, high-resolution microscopy, and a number of other biophysical tools to gain detailed descriptions of these molecules in solution and inside cells. Our most intensive areas of focus in recent years has been on: (1) kinesin motor proteins, which form a large superfamily of cytoskeletal motors that are essential for cellular cargo transport, cell division, and cell shape changes; and (2) on natural toxins that possess anti-fungal and anti-tumor properties. The activities these molecules possess have direct relevance for biomedicine. They also provide frameworks for understanding the fundamental underpinnings of biomolecule design.

Last Modified: 2017-03-24