Publications:

 

Brockhausen I, Nair DG, Chen M, Yang X, Allingham JS, Szarek WA, Anastassiades T.  Human acetyl-CoA:glucosamine-6-phosphate N-acetyltransferase 1 has a relaxed donor specificity and transfers acyl groups up to four carbons in length. Biochem Cell Biol. 2016 Apr;94(2):197-204. PMID: 26935656

Frazer, C., Joshi, M., Delorme, C., Davis, D., Bennett, R.J., Allingham, J.S. Candida albicans kinesin Kar3 depends on a Cik1-like regulatory partner protein for its roles in mating, cell morphogenesis and bipolar spindle formation, Eukaryotic Cell, 2015 Aug 14(8):755-74. PMID: 26024903

Arora, K., Talje, L., Asenjo, A.B., Andersen, P., Atchia, K., Joshi, M., Sosa, H., Allingham, J.S., Kwok, B.H. (2014) KIF14 Binds tightly to microtubules and adopts a rigor-like conformation. J. Mol. Biol. 2014 Aug 26;426(17):2997-3015. PMID: 24949858

Partha, S.K., Ravulapalli, R., Allingham, J.S., Campbell, R.L., Davies, P.L. (2014) Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member. FEBS J. 2014 Jul;281(14):3138-49. PMID: 24846670

Sun, T., Lin, F.H., Campbell, R.L., Allingham, J.S., Davies, P.L. (2014) An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters. Science 2014 Feb 14;343(6172):795-8. PMID: 24531972   

Joshi, M., Duan, D., Drew, D., Jia, Z., Davis, D., Campbell, R.L., Allingham, J.S. (2013) Kar3Vik1 Mechanochemistry Is Inhibited by Mutation or Deletion of the C Terminus of the Vik1 Subunit. J. Biol. Chem. 2013 Dec 27;288(52):36957-70. PMID: 24240171

Guo, S., Garnham, C.P., Karunan Partha, S., Campbell, R.L., Allingham, J.S., Davies, P.L. (2013) Role of Ca²⁺ in folding the tandem β-sandwich extender domains of a bacterial ice-binding adhesin. FEBS J. 2013 Nov;280(22):5919-32. PMID: 24024640

Delorme, C., Joshi, M. & Allingham, J.S. (2012) Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein. Biochem. Biophys. Res. Commun. 2012 Nov 30;428(4):427-32. PMID: 23137538

Duan, D., Jia, Z., Joshi, M., Brunton, J., Chan, M., Drew, D., Davis, D. & Allingham, J.S. (2012) Neck rotation and neck mimic docking in the non-catalytic Kar3-associated protein Vik1. J. Biol. Chem. Nov 23;287(48):40292-301. PMID: 23043140  

Kwok, E., Everingham, S., Zhang, S., Greer, P.A., Allingham. J.S., & Craig, A.W. (2012) FES Kinase Promotes Mast Cell Recruitment to Mammary Tumors Via the Stem Cell Factor/KIT Receptor Signaling Axis. Mol. Cancer Res. 2012 Jul;10(7):881-91. PMID: 22589410

Duan, D., Hnatchuk, D., Brenner, J. Davis, D., & Allingham, J.S. (2012) Crystal structure of the Kar3-like kinesin motor domain from the filamentous fungus Ashbya gossypii. Proteins 2012 Apr;80(4):1016-27. PMID: 22493778

Stark, B.C., Wen, K.K., Allingham, J.S., Rubenstein, P.A., & Lord, M. (2011) Functional adaptation between yeast actin and its cognate myosin motors, J. Biol. Chem. 2011 Sep 2;286(35):30384-92. PMID: 21757693

Xu, C., Liu, B., Han, Y., Feng, L. Allingham, J.S., Szarek, W.A., Wang, L., & Brockhausen, I. (2011) Biochemical Characterization of UDP-Gal:GlcNAc-pyrophosphate-lipid Beta-1,4-Galactosyltransferase WfeD, a new enzyme from Shigella boydii type 14 that catalyses the second step in O-antigen repeating-unit synthesis. J. Bacteriol. 2011 Jan;193(2):449-59. PMID: 21057010

Blain, J. C., Mok, Y-F., Kubanek, J. & Allingham, J. S. (2010) Two Molecules of Lobophorolide Cooperate to Stabilize an Actin Dimer Using Both Their 'Ring' and 'Tail' Region. Chem. Biol. 2010 Aug 27;17(8):802-7. PMID: 20797609

Klein, J. C., Svensson, B., Burr, A. R., Kennedy, D. J., Allingham, J. S., Titus, M. A., Rayment, I. & Thomas, D. D. (2008) Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR. Proc. Natl. Acad. Sci. USA 2008 Sep 2;105(35):12867-72. PMID: 18725645


Lucas-lopez, C. Allingham, J. S., Leb, T., Lawson, C. P., Brenk, R. Sellers, J. R., Rayment, I. & Westwood, N. J. (2008) The small molecule tool (s)-(-)-Blebbistatin: novel insights of relevance to myosin inhibitor design. Org. Biomol. Chem. 2008 Jun 21;6(12):2076-84. PMID: 18528569

Tanaka, J. Blain, J. C. & Allingham, J. S. (2008) Actin-binding toxin 'tail' wags the dog. Chem. Biol. 2008 Mar;15(3):205-7. PMID:18355717
 
Allingham, J.S., Miles, C.O., & Rayment, I. (2007) A Structural Basis for Regulation of Actin Polymerization by Pectenotoxins. J. Mol. Biol. 2007 Aug 24;371(4):959-70. PMID: 17599353

Allingham, J.S., Sproul, L.R., Rayment, I. & Gilbert, S.P. (2007) Vik1 Modulates Microtubule-Kar3 Interactions Through a Motor Domain That Lacks an Active Site. Cell  2007 Mar 23;128(6):1161-72. PMID: 17382884 

Rayment, I. & Allingham, J.S. (2007) Myosin Motors: The Chemical Restraints Imposed by ATP. Lecture Notes in Physics  711, 15-40. (Book Chapter)

Allingham, J. S., Klenchin, V. A., & Rayment, I. (2006) Actin-Targeting Natural Products: Structures, Properties and Mechanisms of Action. Cell. Mol. Life Sci. 2006 Sep;63(18):2119-34. PMID: 16909206

Allingham, J. S., Zampella, A., D'Auria,, M. V., & Rayment, I. (2005) Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity. Proc. Natl. Acad. Sci. USA  2005 Oct 11;102(41):14527-32. PMID: 16192358

Allingham, J. S., Smith, R., & Rayment, I. (2005) The structural basis of blebbistatin inhibition and specificity for myosin II. Nat. Struct. Mol. Biol.  2005 Apr;12(4):378-9. PMID: 15750603