Selected Publications:

Fruci, M, and K. Poole. 2016. Bacterial stress responses as determinants of antimicrobial resistance, pp. 115-136. In Stress and environmental control of gene expression in bacteria, F.J. de Bruijn (ed), Wiley-Blackwell Publishers, New York, NY, USA., in press.

Poole, K., and M. Fruci. 2016. Antimicrobial efflux systems as components of bacterial stress responses. In Efflux-mediated drug resistance in bacteria: mechanisms, regulation and clinical implications, X.-Z. Li, C. Elkins and H. Zgurskaya (eds), Springer Publishing, New York, NY, USA., in press.

Poole, K., C. Gilmour, M.A. Farha, E. Mullen, C.H.-F. Lau, and E.D. Brown. 2016. Potentiation of aminoglycoside activity in Pseudomonas aeruginosa by targeting the AmgRS envelope stress-responsive two-component system. Antimicrob. Agents Chemother. 60:3509-3518.

Poole, K., C.H.-F. Lau, C. Gilmour, Y. Hao, and J.S. Lam. 2015. Polymyxin susceptibility in Pseudomonas aeruginosa linked to the MexXY-OprM multidrug efflux system. Antimicrob. Agents Chemother. 59:7276-7289.

Purssell, A., M. Fruci, A. Mikalauskas, C. Gilmour, and K. Poole. 2015. EsrC, an envelope stress-regulated repressor of the mexCD-oprJ multidrug efflux operon in Pseudomonas aeruginosa. Environ. Microbiol. 17:186-198.

Lau, C. H.-F., C. Gilmour, E. Mullen, and K. Poole. 2015. AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa. MicrobiologyOpen 4:121-135.

Lau, C.H.-F., D. Hughes, and K. Poole. 2014. MexY-promoted aminoglycoside resistance in Pseudomonas aeruginosa: involvement of a putative proximal binding pocket in aminoglycoside recognition. mBio 5:e01068.

Poole, K. 2013. Pseudomonas efflux pumps, pp. 175-206. In Microbial efflux pumps, E. Yu, Q. Zhang, and M.H. Brown (eds), Caister Academic Press, Norfolk, UK (invited book chapter).

Purssell, A. and K. Poole. 2013. Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa. Microbiology 159:2058-2073.

Hay, T., S. Fraud, C.H.F. Lau, C. Gilmour and K. Poole. 2013. Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-reperssor ArmZ. PLoS ONE 8: e56858.

Lau, C. H.-F., S. Fraud, M. Jones, S. N. Peterson, and K. Poole. 2013. Mutational activation of the AmgRS two-component system in pan-aminoglycoside-resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 57:2243-2251.

Poole, K. 2012. Stress responses as determinants of antimicrobial resistance in Gram-negative bacteria. Trends in Microbiol. 20: 227-234. (invited review)

Starr, L.M., Fruci, M.J., and K. Poole. 2012. Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon: involvement of the NalC and MexR repressors and the MexR anti-repressor ArmR. PLoS ONE 7:e32684.

Lau, C. H.-F., S. Fraud, M. Jones, S. N. Peterson, and K. Poole. 2012. Reduced expression of the rplU-rpmA ribosomal protein operon in mexXY expressing pan-aminoglycoside-resistant Pseudomnonas aeruginosa. Antimicrob. Agents Chemother. 56: 5171-5179.

Krahn,T., C. Gilmour, J. Tilak, S. Fraud, N. Kerr, C.H.F. Lau, and K. Poole. 2012. Determinants of intrinsic aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 56:5591-5602.

Poole, K. 2011. Pseudomonas aeruginosa: resistance to the max. Front. Microbiol. doi:  10.3389/fcmi.2011.00065.


Fetar, H., C. Gilmour, R. Klinoski, D.M. Daigle, C.R. Dean and K. Poole. 2011. The mexEF-oprN multidrug efflux operon of P. aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrob. Agents Chemother. 55:508-514

Fraud, S. and K. Poole. 2011. Oxidative stress induction of the MexXY multidrug efflux genes and promotion of aminoglycoside resistance development in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 55:1068-1074

Morita Y, C Gilmour, D Metcalf, and K Poole.  2009.  Translational control of the antibiotic inducibility of the PA5471 gene required for mexXY multidrug efflux gene expression in Pseudomonas aeruginosa. J. Bacteriol. 191:4966-4975.

Fraud S, A Campigotto, Z Chen, and K Poole.  2008. The MexCD-OprJ multidrug efflux system in Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane damaging agents dependent upon the AlgU stress-response sigma factor.  Antimicrob. Agents Chemother. 52:4478-4482.

Wilke MS, M Heller, L Creagh, C Haynes, LP McIntosh, K Poole and NCJ Strynadka. 2008. The crystal structure of MexR from Pseudomonas aeruginosa in complex with its anti-repressor ArmR. Proc. Natl. Acad. Sci., 105:14832-14837.