Laurie Graham, Ph.D

Laurie Graham

Faculty Bio

My research in the Peter Davies lab involves the study of antifreeze proteins (AFPs) that bind to ice crystals and prevent ice growth at subzero temperatures. We are currently purifying, characterizing and cloning genes for new AFPs from a variety of organisms. The genes will be expressed in a suitable system, and we will attempt to crystallize the purified proteins and solve their structures. This will help us to identify the structural features required for ice binding and provide clues as to their mechanism of action. We are also studying AFP gene families from a variety of organisms to determine whether those that produce similar AFPs do so because they have arisen by 1) convergent evolution 2) divergent evolution from a common ancestor or 3) lateral gene transfer.

Last Modified: 2012-10-19