Michele Loewen, Ph.D.

Michele Loewen

Faculty Bio

Adjunct Assistant Professor (2015 - ongoing) - Queen's University
Research Officer (2001 - ongoing) - National Research Council of Canada

Education:

B.Sc. (Hons.) in Biochemistry (1992) - University of Manitoba
Ph.D. in Biochemistry (1997) - Queen’s University
Postdoctoral Associate (1997-1998) - Department of Microbiology, University of Basel
Postdoctoral Fellow (1997-2001) - Department of Biology, Massachusetts Institute of Technology

Current Funding:
Natural Sciences and Engineering Research Council
National Research Council of Canada

 Research Interests:

  • Roles of ABC Transporters and associated metabolites in fungal disease resistance
  • Roles of G-protein coupled receptors in fungal growth
  • Structure-function relationships of proteins
  • Industrial enzyme engineering

On the one hand our lab is currently investigating mechanistic aspects of fungal disease resistance.  In particular we are elucidating transport specificities and associated mechanisms of action for ABC transporters known to mediate fungal resistance. We use in vitro transport assays, relying on recombinantly produced and enriched transporters, reconstituted into proteoliposomes, and analytical methods such as mass spetropscopy and nuclear magnetic resonance to detect allocrites.  At the same time, toward understanding mechanisms in fungal growth and its inhibition,  we are investigating the role of G-protein coupled receptors in fungal cell cycle and mating events. 

On the other hand we have more recently also become engaged in industrial enzyme engineering toward the development of novel bioprocessing technologies to apply to industrial waste streams for the production of value added products in the natural health products, food colorings and nutrition fields.

 

Last Modified: 2016-11-02