Research in my lab focuses on anti-tumour immunity and treatment response in ovarian and prostate cancers.
Major themes and areas of research:
- Role of Type I Interferon pathways in sensitivity or resistance to chemotherapy in ovarian cancer using cancer cell lines, in vivo mouse models and patient derived material.
- Immuno-genomic studies to delineate genetic correlates of intra-tumour immune diversity and association with intrinsic and acquired resistance to therapy.
- Role of cancer cell intrinsic genetic events and their association with distinct immune microenvironment states in prostate cancer.
- Development of improved non-invasive immune monitoring approaches towards their application as prognostic and predictive indicators for personalized treatment approaches in cancer.