Mark Ropeleski, MD

Mark Ropeleski

Faculty Bio

My clinical interests focus on the chronic idiopathic inflammatory bowel diseases such as Ulcerative Colitis and Crohn's disease. Our research interests focus on the epithelial layer of the intestine and the identification and study of epithelial cytoprotective genes and signaling pathways. The long-term goal our the lab is to characterize novel epithelial mechanisms of cellular defence in order to exploit these endogenous protective pathways and apply this new knowledge to counteract key pathologic processes characteristic of intestinal inflammation seen in Inflammatory Bowel Disease. Our principal focus is the cytokine Interleukin-11. The role of IL-11 in protecting the vulnerable proliferative compartment of the epithelial crypt from injury through the antagonism of apoptosis is a principal focus of currently funded projects. The importance of cytoprotection and signaling by IL-11 in the intestinal epithelium is be tested in various models of intestinal inflammation with a focus on how IL-11 facilitates recovery of the epithelium and stimulates healing. Cognizant of how GI cancers exploit survival signaling, we have a shared interest in colon cancer that develops in the setting of chronic inflammation of the colon.

Last Modified: 2016-03-03