Szewczuk, Myron R. Lab

Present Graduate Trainees
Ph.D. students
Fiona Haxho
- Queen’s Graduate Award (QGA), the Graduate Entrance Tuition Award (GETA), the Natural Sciences and Engineering Research Council of Canada (NSERC) Alexander Graham Bell Canada Graduate Scholarship-Master’s (CGS M) and now the 2016 Vanier Canada Graduate Scholarship. (started MSc 09/14, mini-MSc defence 08/16 into PhD, successfully completed PhD Comprehensive exam June 20, 2017, successfully completed PhD dissertation defence July 31, 2017) - accepted MD program at University of Toronto starting September 2017.

Manpreet (Ruby) Sambi - Queen’s Graduate Award (QGA), and 2018 The Office of Postgraduate Medical Education Queen’s University Recognition Award.

Bessi Qorri - successfully completed the mini-Master (August 21, 2018).
2018 Dean's Doctoral Award, 2017 Queen’s Graduate Award (QGA), 2017 Encyt Technologies, Inc., 2017 Terry Fox Research Institute Transdisciplinary Training Program in Cancer Research, and 2018 The Office of Postgraduate Medical Education Queen’s University Recognition Award.

M.Sc. students
Sabah Haq, M.D.Queen’s Graduate Award (QGA), and 2016 Ontario Graduate Scholarship (OGS) - (started September 2015 -completed June 21, 2017; accepted PhD position offer at McMaster University). 

Bessi Qorri
- May 2017, successfully completed the mini-Master (August 21, 2018), Queen’s Graduate Award (QGA), Encyt Technologies, Inc. and  2017 Terry Fox Research Institute Transdisciplinary Training Program in Cancer Research

Vanessa Samuel
-Combined BScH/MSc (declined). Accepted UBC MD program, MD offers at Calgary and  Queen's

Nicka Kalaydina
- September 2017, Queen’s Graduate Award (QGA), Encyt Technologies, Inc., and 2018 The Office of Postgraduate Medical Education Queen’s University Recognition Award.

Graduate Diploma and Professional Master in Medical Sciences (GDPM)
July 2017                                                January 2018                              July 2018

Andrey Vishnyakov, MD                          Iryna Liauchonak, MD                Arifuddin Saad Mohammed, MD
Anmol Lamba, MD                                  Fady Dawoud, MBBCh               Shamira Pira, MD
Catherine Nowierski, MSc, MD               Yatin Riat, MD                           Jabiz Modaresi Esefh, MD, PhD
S.M. Signy Frank, MBBS                        Justin Jain, MD
Umrao Bhatti, MBBS                              Komal Bajwa, MBBS
Yara Mouhamed, MBBCh

GDPM Publications:
Iryna Liauchonak1,4, Bessi Qorri2,4Fady Dawoud1,4,Yatin Riat1,3,4, and Myron R. Szewczuk2,* Non-nutritive Sweeteners and their Implications on the Development of Metabolic Syndrome.  Nutrients 2019, 11, 644. http://dx.doi.org/10.3390/nu11030644  (impact factor 4.6, indexed PubMed). Received: 28 February 2019; Accepted: 13 March 2019 after extensive peer-review; Published:16 March 2019.  1Graduate Diploma and Professional Master in Medical Sciences, Postgraduate Medical Education, School of Medicine, Queen’s University, Kingston, ON, Canada; 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 3Present address: Emergency Medicine, Resident Physician, Brooklyn Hospital Centre, 121 DeKalb Avenue, Brooklyn, N.Y. 11201, USA. 4Contributing first authorship

Justin Jain1,3, Bessi Qorri2, 3 and Myron R. Szewczuk1,2,*.
The Crucial Role of Primary Care Providers in the Long-term
follow up of Adult Survivors of Childhood Cancer. 2018 Cancer Management and Research (impact factor 3.702, indexed PubMed). submitted for publication December 09, 2018, under peer-review, accepted for publication February 02, 2019. 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 1Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 3Contributing first authorship

Regina-Veronicka Kalaydina1,4, Komal Bajwa2,4, Bessi Qorri1,4, Alexandria Decarlo3, and Myron R. Szewczuk1,* Recent advances in “smart” delivery systems for extended drug release in cancer therapy. International Journal of Nanomedicine 2018:13 4727–4745, extensive peer-reviewed, indexed in PubMed Central  (impact factor: 5.008). DOI https://doi.org/10.2147/IJN.S168053.  1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 3Department of Biology, Queen’s University, Kingston, ON, Canada; 4Contributing first authorship

Iryna Liauchonak MD 1,3, Fady Dawoud MBBCh 1,3, Yatin Riat MD 1,3, Bessi Qorri BSc 2,3, Manpreet Sambi MSc 2,3, Justin Jain MD 1, Regina-Veronicka Kalaydina BSc 2, Nicole Mendonza 2, Komal Bajwa MBBS 1, and Myron R. Szewczuk PhD 2,*   Biased G-protein coupled receptor agonism bridges the gap between the insulin receptor and metabolic syndrome. Int. J. Mol. Sci. 2018, 19, 575.  (Impact factor: 3.2), indexed in PubMed Central; Received: 1 February 2018 / Revised: 11 February 2018 / Accepted: 15 February 2018 / Published: 17 February 2018. 1Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 2 Department of Biomedical and Molecular Science, Queen’s University, Kingston ON, Canada;  3 Contributing first authorship.   doi:10.3390/ijms19020575

Yara Mouhamed1,3, Andrey Vishnyakov1,3, Bessi Qorri2,3, Manpreet Sambi2,3, Signy Frank1, Catherine Nowierski1, Anmol Lamba1, Umrao Bhatti1, and Myron R Szewczuk2,*. Therapeutic Potential of Medicinal Marijuana: An Educational Primer for Healthcare Professionals. 2018 Drug, Healthcare and Patient Safety 10: 45–66indexed in PubMed Central; submitted 16/Jan/2018, extensive peer-review, accepted for publication March 9, 2018. 1Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University. 2Department of Biomedical and Molecular Sciences, Queen’s University. 3Contributing first authorship.
https://www.dovepress.com/therapeutic-potential-of-medicinal-marijuana-an-educational-primer-for-peer-reviewed-article-DHPS

Manpreet Sambi1,3, Bessi Qorri1,3, S.M. Signy Frank2, Yara Mouhamed2, Regina-Veronicka Kalaydina1, Nicole Mendonza1, and Myron R. Szewczuk1*. Novel Use of Peptides to Facilitate the Formation of 3D Multicellular Tumor Spheroids. 2017 Curr Top Pept Protein Res 18, 25-34indexed in PubMed Central; 1Department of Biomedical and Molecular Sciences, Queen’s University. 2Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University. 3Contributing first authorship. http://www.researchtrends.net/tia/article_pdf.asp?in=0&vn=18&tid=26&aid=6049

Undergraduate 4th yr research project students

Shanel Mackay (2018-19) - Life Sciences Specialization.

Alexandra DeCarlo (2018-19) -
Bachelor of Science, Specialization in Biotechnology (Honours)
Publications:
  1. Bessi Qorri1, Regina-Veronicka Kalaydina1, Aleksandra Velickovic1, Yekaterina Kaplya1, Alexandria Decarlo2. and Myron R. Szewczuk1,* Agonist-biased signaling via matrix metalloproteinase-9 promotes extracellular matrix remodeling. Cells 2018, 7, 117; http://dx.doi.org/10.3390/cells7090117 (impact factor 4.829);  full-text archived in PubMed Central. 1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Department of Biology, Biosciences Complex, Queen’s University, Kingston, ON, Canada K7L 3N6. *corresponding author
  2. Regina-Veronicka Kalaydina1,4, Komal Bajwa2,4, Bessi Qorri1,4, Alexandria Decarlo3, and Myron R. Szewczuk1,* Recent advances in “smart” delivery systems for extended drug release in cancer therapy. International Journal of Nanomedicine 2018:13 4727–4745, extensive peer-reviewed, indexed in PubMed Central (impact factor: 5.008)DOI https://doi.org/10.2147/IJN.S168053.  1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 3Department of Biology, Queen’s University, Kingston, ON, Canada; 4Contributing first authorship
  3. Xia Li1,6 & Manpreet Sambi2,6, Alexandria DeCarlo3, Sergey V Burov4, Roman Akasov5, Elena Markvicheva5, Cecile Malardier-Jugroot1,* and Myron R Szewczuk2,* Functionalized folic acid-conjugated amphiphilic alternating copolymer actively targets 3D multicellular tumor spheroids and delivers the hydrophobic drug to the inner core. Nanomaterials 2018, 8, 588; doi:10.3390/nano8080588, extensive peer-reviewed, indexed in PubMed Central (Impact Factor: 3.811)1Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada; 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 3Department of Biology, Queen’s University, Kingston, ON, Canada; 4Synthesis of Peptides and Polymer Microspheres Laboratory, Institute of Macromolecular Compounds, Russian Academy of Sciences, St Petersburg, Russia; 5Department of Biomaterials and Biotechnologies, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 6Contributing first authors, *corresponding authors.
Vanessa Samuel  (2016-17) - Life Sciences Specialization. Recipient of the Queen’s University Principal’s Scholarship and the Board of Governor’s Award.
Publications:
  1. Roman Akasov, Sabah Haq, Fiona Haxho, Vanessa Samuel, Sergey V. Burov, Elena Markvicheva, Ronald J. Neufeld, and Myron R. Szewczuk. Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD peptide induced self-assembly. 2016 Oncotarget 2016, Vol. 7, No.40 66119-661342016. (impact factor 6.4)
  2. Manpreet Sambi, Sabah Haq, Vanessa Samuel, Bessi Qorri, Fiona Haxho, Kelli Hill, William Harless and Myron R. Szewczuk. Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity. Breast Cancer - Targets and Therapy 2017:9 1–9.
  3. Sabah Haq, Fiona Haxho, Vanessa Samuel, Roman Akasov, Maria Leko, Sergey V. Burov, Elena Markvicheva and Myron R. Szewczuk.Sialylation facilitates self-assembly of 3D multicellular prostaspheres using cyclo-RGDfK(TPP) peptide. OncoTargets and Therapy 2017:10 2427–2447, accepted March 08, 2017, as it stands in current form.   DOI https://doi.org/10.2147/OTT.S133563
Bessi Qorri (2016-17) - Life Sciences Specialization
Publications:
  1. Manpreet Sambi, Sabah Haq, Vanessa Samuel, Bessi Qorri, Fiona Haxho, Kelli Hill, William Harless and Myron R. Szewczuk. Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity. Breast Cancer - Targets and Therapy 2017:9 1–9.
  2. Fiona Haxho1 & Manpreet Sambi1, Bessi Qorri1, William Harless, Myron R. Szewczuk. Current clinical challenges and emerging multi-modal approaches for the treatment of pancreatic cancer.  Clin Oncol. 2017; 2: 1296, submitted March 11, 2017, accepted for publication April 13, 2017 as it stands in current form.  1contributing first authors.
  3. Manpreet Sambi1,2 & Fiona Haxho1,2, Bessi Qorri1, William Harless3*, Myron R. Szewczuk1*. Pancreatic Adenocarcinoma: Current Therapies and Challenges. Adv Res Gastroentero Hepatol 4(4): ARGH.MS.ID.555643 (2017) 001, submitted April 15, 2017, accepted for publication April 18, 2017 as it stands in current form. 2contributing first authors. 3ENCYT Technologies, Inc. Membertou, NS, Canada. DOI: 10.19080/ARGH.2017.04.555643
  4. Manpreet Sambi1 & Bessi Qorri1 and Myron R Szewczuk. Therapeutic options for Metastatic Breast Cancer. Springer Book ‘Breast Cancer Metastasis and Drug Resistance’ – 2nd Volume, in preparation for July 2017 due date. 1contributing first authors.

All of my graduate students finish “on time, MSc 1.5 yrs and PhD 3yrs” with several publications in high impact (IF≥ 4.3) journals as first and contributing co-authors.

My undergrad 4th yr research project students and NSERC USRA funded students (~ 50%) have contributed as co-authors to our publications.

A high proportion of my trainees  have continued in academic or medical careers. Most gratifying and compelling success of my past PhD trainees are now academic faculty members as full professors and/or departmental heads or senior staff scientists in biotech companies.

My recent graduated PhD trainees have MD or post-doctoral positions (Dr. Fiona Haxho - MD program at the University of Toronto; Dr. Ray Amith- Post-doctoral training at the University of Alberta; Assistant Professor at Keele University, U.K.; Dr. Preethi Jayanth-Post-doctoral trainee at McMaster University); Dr. Samar Abdulkhalek-Post-doctoral training at Cleveland Clinic 1yr; Assistant Professor in UAE)