Research InterestsMy research is centered on the cellular mechanisms governing vascular remodeling in health and disease, with a particular focus on the capacity of circulating cells of the immune system to regulate blood vessel integrity, growth and repair. This interest is rooted in my study of pulmonary arterial hypertension (PAH), a disease of pathological vascular remodeling and right heart failure that is linked to immune dysfunction. PAH is strongly associated with loss-of-function mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR-II), a receptor of the transforming growth factor-β (TGFβ) superfamily. Identification of this link between PAH and BMPR-II haploinsufficiency has provided considerable insight into the mechanisms governing pulmonary vascular homeostasis and makes PAH an ideal candidate for proof-of-concept regenerative and cell-based therapeutic strategies.
Video from the Kingston General Hospital Research Institute