Selected Publications:

Publications (2011-2016)

104.  Rao, S.-.S., Mu, Q., Zeng, Y., Cai, P.-.C., Yang, J., Xia, Y., Zhang, Q., Song, L.-.J., Zhou, L.-.L., Li, F.-.Z., Lin, Y.-.L., Fang, J., Greer, P.A., Shi, H.-.Z., Ma, W.-.L., Su, Y., and Ye, H. 2016. Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodeling in asthma. Clinical & Experimental Allergy (In press) Epub Sept 20, 2016

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27649066

 

103.  Li, S., Zhang, Zhang, L., Xiong, S, Greer, P.A., Fan, G.-G., and Peng, T.  2016. Disruption of calpain reduces lipotoxcity-induced cardiac injury by preventing endoplasmic reticulum stress. BBA – Molecular Basis of Disease 1862:2023-33

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27523632

 

102.  Fan, G., Zhang, S., Gao, Y., Greer, P.A. and Tonks, N.K. 2016. HGF-independent regulation of MET and GAB1 by non-receptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes and Development 30: 1542-57

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27401557

 

101. Yang, J., Xiang, F., Cai, P.-C., Lu, Y.-Z., Xu, X.-X., Yu, F., Li, F.-Z., Greer, P.A., Shi, H.-Z., Zhou, Q., Xin, J.-B., Ye, H., Su, Y., and Ma, W.-L.  2016. Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis. American Journal of Physiology Lung Cellular and Molecular Physiology 311:L145

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27261452

 

100.  Alvau, A., Battistone, M.A., Gervasi, M.G., Salicioni, A.M., Navarrete, F.A., Sanchez, C., De la Vega-Beltran, J.L., Greer, P.A., Darszon, A., Cuasnicu, P., Visconti, P.E. 2016. The tyrosine kinase Fer is responsible for the capacitation-associated increase in tyrosine phosphorylation. Development 143: 2325-33

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27226326

 

99. Grieve, S., Gao, Y., Hu, J., Hall, C., and Greer, P.A. 2016. Calpain genetic disruption and HSP90 inhibition combine to attenuate mammary tumorigenesis. Molecular & Cellular Biology 36:2078-88

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27215381

 

98. Ni, R., Zheng, D., Xiong, S., Hill, D., Sun, T., Gardnier, R., Fan, G.-C., Lu, Y., Abel, D., Greer, P.A., Peng, T. 2015. Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy. Diabetes 65:255-68

http://diabetes.diabetesjournals.org/content/early/2015/10/08/db15-0963.long

 

97.  Ni, R, Zheng, D., Wang, Q., Yu, Y., Chen, R., Sun, T., Wang, W., Zhang, H., Fan, G.-C., Greer, P.A. Gardiner, R., and Peng, T. 2015. Deletion of capn4 protects the heart against endotoxemic injury by preventing ATP synthase disruption and inhibiting mitochondrial superoxide generation.  Circulation: Heart Failure 8:988-996.

http://www.ncbi.nlm.nih.gov/pubmed/26246018?dopt=Citation

 

96. Hoskin, V., Szeto, V., Ghaffari, A., Greer, P.A., Côté, G.P., and Elliott, B.E., 2015. Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion.  Molecular Biology of the Cell. 26:3464-79

http://www.ncbi.nlm.nih.gov/pubmed/26246600?dopt=Citation

 

95. Zhang, S., Kim, H., Mullins, G.S., LeBrun, D., Elliott, B.E., and Greer, P. A. 2015. Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response. Journal of Clinical & Cellular Immunology 6:329-47

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27563494

 

94.  Li, F.-Z., Cai, P.-C., Song, L.-J., Zhou, L.-L., Zhang, Q., Xiang, F., Zhang, J.-C., Rao, S.-S., Xia, Y., Xiang, F., Xin, J.-B., Greer, P.A., Shi, H.-Z., Su, Y., Ma, W.-L., Ye, H. 2015. Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis. BBA-Molecular Basis of Disease 1852:1796 http://www.sciencedirect.com/science/article/pii/S092544391500174X

 

93. Yang, J., Wu, Z., Renier, N., Simon, D.J., Uryu, K., Park D.S., Greer, P.A., Tournier, C., Davis, R.J., and Tessier-Lavigne, M. 2015. Pathological axonal death through a MAPK cascade that triggers local energy deficit.  Cell 160:161-176

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=25594179

 

92. Lu, S., Kanekura, K., Hara, T., Mahadevan, J., Spears, L.D., Oslowski, C.M., Marinez, R., Yamazaki-Inoue, M., Toyoda, M., Neilson, A., Blanner, P.M., Brown, C., Semenkovich, C.F., Marshall, B.A., Hershey, T., Umezawa, A., Greer, P.A., and Urano, F.  2014. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.  PNAS 111: E5292-301

http://www.pnas.org/content/early/2014/11/20/1421055111.full.pdf+html

 

91. Williams, J.L., Greer, P.A., and Squire, J.A. 2014. Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data. Cancer Genetics 207:474-488

http://www.sciencedirect.com/science/article/pii/S2210776214001793

 

90.  Sangrar, W. Shi, C., Mullins, G.S., LeBrun, D., Ingalls, B., and Greer, P.A. 2014. Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems. Oncogene 34:4109-17

http://www.ncbi.nlm.nih.gov/pubmed/25347743

 

89.  Redpath, G.M., Woolger, N., Piper, A.K., Lemckert, F.A., Lek, A., Greer, P.A., North, K.N., Cooper, S.T. 2014. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol. Biol. Cell. 25:3037-3048

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230592/

 

88. Kumar, V., Everingham, S., Hall, C., Greer, P.A. and Craig, A.W.B. 2014. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. European Journal of Immunology 44:831

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=24375267

 

87.  Elagib, K.E., Rubinstein, J.D., Delehanty, L.L., Ngoh, V., Greer, P.A., Li, S., Lee, J.K., Orkin, S.H., Mihaylov, I.S. and Goldfarb, A.N.  2013 Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation. Developmental Cell 27:607

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=24369834

 

86.  Nagaria, T., Williams, J.L., Leduc, C., Squire, J.A., Greer, P.A, and Sangrar, W. 2013 Flavopiridol synergizes with Sorafenib to induce cytotoxicity and potentiate anti-tumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems. Neoplasia 15:939-51

http://www.ncbi.nlm.nih.gov/pubmed/23908594

 

85.  Miyata, Y., Kanda, S., Sakai, H., and Greer, P.A. 2013. Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma. Cancer Science 104:681

http://www.ncbi.nlm.nih.gov/pubmed/23445469?dopt=Citation

 

84. Amini, M., Ma, C. Farazifard, R., Zhang, Y.H., Vanderluit, J.,  Zoltewicz, J.S., Hage, F., Savitt, J.M., Lagace, D., Slack, R.S., Beique, J.C., Greer, P.A., Richard Bergeron, R., Park, D.S. 2013.  Conditional disruption of calpain in CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. J. Neuroscience 33:5773-84

http://www.ncbi.nlm.nih.gov/pubmed/23536090

 

83. Khajah, M., Andonegui, G., Chan, R., Craig, A.W., Greer, P.A. and McCafferty, D.M. 2013. Fer Kinase Limits Neutrophil Chemotaxis towards End Target Chemoattractants.  J. Immunol. 190:2208-16

http://www.ncbi.nlm.nih.gov/pubmed/23355730?dopt=Citation

 

82. Ma, J., Wie, M., Wang, Q., Li, J., Wang, H., Liu, W., Liu, W., Lacefield, J.C., Greer, P.A., Karmazyn, M., Fan, G., and Peng, T. 2012. Deficiency of Capn4 inhibits NF-kB signaling/inflammation and reduces remodeling after myocardial infarction. J. Biol. Chem. 287:27480

http://www.ncbi.nlm.nih.gov/pubmed/22753411?dopt=Citation

 

81.  Kwok, E., Everingham, S., Zhang, S., Greer, P.A., Allingham, J.S. and Craig, A.W.B. 2012.

FES kinase promotes mast cell recruitment to mammary tumors via the stem cell factor/KIT receptor signaling axis. Molecular Cancer Research 10:881-91

http://www.ncbi.nlm.nih.gov/pubmed/22589410?dopt=Citation

 

80.  Ho., W.C., Pikor, L, Gao, Y., Elliott, B.E., and Greer, P.A. 2012. Calpain 2 regulates the Akt-FoxO-p27Kip1 signaling pathway in mammary carcinoma. J. Biol. Chem. 287:15458-15465

http://www.ncbi.nlm.nih.gov/pubmed/22427650?dopt=Citation

 

79. Greer, P.A., Kanda, S., and Smithgall, T.E. 2012. The contrasting oncogenic and tumor suppressor roles of FES.  Frontiers in Bioscience 4:489-501

http://www.ncbi.nlm.nih.gov/pubmed/22202072?dopt=Citation

 

78. Ma, W., Han, W., Greer, P.A., Tuder, R., Toque, H.F., Wang, K.K.W. Caldwell, R.W. and Su, Y. 2011. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuated pathologic features of disease. J. Clinical Invest. 121:4548-66

http://www.ncbi.nlm.nih.gov/pubmed/22005303?dopt=Citation

 

77. Li, Y., Ma, J., Zhu, H., Singh, M., Hill, D., Greer, P.A., Arnold, J. A., Abel, E.D. and Peng, T., 2011. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type-I diabetes. Diabetes 60:2985-94

http://www.ncbi.nlm.nih.gov/pubmed/21911754?dopt=Citation

 

76. Miyata, Y., Watanabe, S., Matsuo, T., Maruta, S., Hayashi, T., Sakai, H., Xuan, J.W., Greer, P.A. and Kanda, S.  2011. Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer. Prostate 72:201-8

http://www.ncbi.nlm.nih.gov/pubmed/21563194?dopt=Citation

 

75.  Zhang, S., Chitu, V., Stanley, R., Elliott, B., and Greer, P.A. 2011. Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis and infiltrating macrophages. Cancer Research 71:1465-1473

http://www.ncbi.nlm.nih.gov/pubmed/21159660?dopt=Citation