Selected Publications:

  1. Sun T, Gauthier SY, Campbell RL, Davies PL (2015) Revealing Surface Waters on an Antifreeze Protein by Fusion Protein Crystallography Combined with Molecular Dynamic Simulations. J Phys Chem B. 119.12808-15. PubMed 26371748. (doi: 10.1021/acs.jpcb.5b06474)
  2. Basu, K, Graham, LA, Campbell, RL and Davies, PL (2015) Flies expand the repertoire of protein structures that bind ice. Proc Natl Acad Sci U S A.  112(3), 737-42. PubMed: 25561557 (doi: 10.1073/pnas.1422272112.)
  3. Low, KE, Partha, SK, Davies, PL, Campbell, RL (2014) Allosteric inhibitors of calpains: Reevaluating inhibition by PD150606 and LSEAL. Biochim Biophys Acta. 1840(12), 3367-3373.PubMed: 25196359
  4. Vance, TDR, Olijve, LLC, Campbell, RL, Voets, IK, Davies, PL, Guo, S, (2014) Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice. Bioscience Reports. 34(4). PubMed: 24892750
  5. Partha, SK, Ravulapalli, R, Allingham, JS, Campbell, RLDavies, PL (2014) Crystal structure of calpain-3 penta-EF-hand domain: A homodimerized PEF family member with calcium bound at the fifth EF-hand. FEBS Journal. 281(14), 3138-49. PubMed: 24846670
  6. Sun,T, Lin, F-H, Campbell, RL, Allingham, JS, and Davies, PL (2014) An antifreeze protein folds with an interior network of over 400 semi-clathrate waters. Science 343(6172), 795-8. PubMed: 24531972
  7. Guo, S, Garnham, CP, Partha, SK, Campbell, RL, Allingham, JS, Davies, PL (2013) Role of Ca2+ in folding the tandem β-sandwich extender domains of a bacterial ice-binding adhesion. FEBS Journal Ref. no.: FJ-13-0467.R1.PubMed: 24024640
  8. Campbell RLDavies PL (2012) Structure-function relationships in calpains. Biochem J. 447, 335-51 PubMed: 23035980
  9. Middleton, AJ, Marshall, CB, Faucher, F, Bar-Dolev, M, Braslavsky, I, Campbell, RL, Walker, VK and Davies, PL (2012) Antifreeze protein from freeze-tolerant grass has a beta-roll fold with an irregularly structured ice-binding site. J. Mol. Biol. 416, 713-724 PubMed: 22306740
  10. Garnham, CP, Campbell, RL, Walker, VK and Davies, PL (2011) Novel dimeric beta-helical model of an ice nucleation protein with bridged active sites. BMC Structural Biology. 11:36  PubMed: 21951648
  11. Garnham, CP, Campbell, RL and Davies, PL (2011) Anchored clathrate waters bind antifreeze proteins to ice. Proc Natl Acad Sci 108, 7363-7367.  PubMed: 21482800 PubMed Central: PMC3088597
  12. Kelly, JC, Cuerrier, D, Graham, LA, Campbell, RL, and Davies, PL (2009) Profiling of calpain activity with a series of FRET-based substrates. Biochim Biophys Acta. 1794, 1505-1509. PubMed: 19555780
  13. Garnham, CP, Hanna, RA, Chou, JS, Low, KE, Gourlay, K, Campbell, RL, Beckmann, JS and Davies, PL (2009) Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3. Biochemistry 48, 3457-3467.  PubMed: 19226146
  14. Ravulapalli, R, Campbell, RL, Gauthier, SY, Dhe-Paganon, S and Davies PL (2009) Distinguishing between calpain heterodimerization and homodimerization. FEBS J. 276, 973-982.  PubMed: 19215300
  15. Hanna, RA, Campbell, RL and Davies, PL (2008) Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. Nature 456, 409-412.  PubMed: 19020623
  16. Qian, J, Cuerrier, D, Davies, PL, Li, Z, Powers, JC and Campbell, RL (2008) Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions. J. Med. Chem. 51, 5264-5270. PubMed: 18702462
  17. Graham, LA, Marshall, CB, Lin, F-H, Campbell, RL and Davies, PL (2008) Hyperactive antifreeze protein from fish contains multiple ice-binding sites. Biochemistry 47, 2051-2063. PubMed: 18225917
  18. Garnham, CP, Gilbert, JA, Hartman, CP, Campbell, RL, Laybourn-Parry, J and Davies PL (2008) A Ca2+-dependent bacterial antifreeze protein domain has a novel beta-helical ice-binding fold. Biochem J. 411, 171-180.  PubMed: 8095937
  19. Cuerrier, D, Moldoveanu, T, Campbell, RL, Kelly, J, Yoruk, B, Verhelst, SHL, Greenbaum, D, Bogyo, M and Davies, PL (2007) Development of calpain-specific inactivators by screening of positional-scanning epoxide libraries. J. Biol. Chem. 282, 9600-9611.  PubMed: 17218315
  20. Cuerrier, D, Moldoveanu, T, Inoue, J, Davies, PL, Campbell RL (2006) Calpain Inhibition by Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45, 7446-7452.  PubMed: 16768440