Research Interests:

My research program involves the use of structural biology (i.e., nuclear magnetic resonance (NMR), X-ray crystallography, small-angle X-ray scattering), biophysical methods and complementary cell biology approaches to identify the molecular determinants regulating macromolecular complex assembly and function. We are currently studying the following systems: 1) mucin-degrading enzymes and enzyme complexes from the opportunistic pathogen Clostridium perfringens 2) the assembly, organization, and higher order structure of the cellulosome, a highly efficient lignocellulose-degrading bacterial enzyme complex, and 3) the molecular determinants of E2A transcriptional factor-target protein interactions that regulate lymphopoiesis and acute lymphoblastic leukemia.