← Back

Dr. Gil Mor

Event Start: Apr 25, 2018 1:00 pm
Location: Biosciences Complex, Room 1102

Dr. Gil Mor
Professor and Director
Division of Reproductive Sciences
Director, Discovery to Cure Translational Research Program
Department of obstetrics, Gynecology & Reproductive Sciences
Yale University School of Medicine

Cancer stem cells: implications for chemoresistance and recurrence

A major burden in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells (CSCs), provides a reservoir of cells that can self-renew, maintain the tumor by generating differentiated cells (non-stem cells (non-CSCs)) which make up the bulk of the tumor and may be the primary source of recurrence. We describe the characterization of human ovarian cancer stem cells (OCSCs). These cells have a distinctive genetic profile that confers them with the capacity to recapitulate the original tumor, proliferate with chemotherapy, and promote recurrence. Chemotherapy eliminates the bulk of the tumor but it leaves a core of cancer cells with high capacity for repair and renewal. The molecular properties identified in these cells may explain some of the unique characteristics of CSCs that control self-renewal and drive metastasis. The identification and cloning of human OCSCs can aid in the development of better therapeutic approaches for ovarian cancer patients.

April 25th, 2018
1:00 - 2:00pm
Biosciences Complet, Room 1102