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Dr. Denis Grant

Event Start: May 30, 2018 3:00 pm
Location: School of Medicine, 132A

The Twenty-Second McEwen Lecutureship

Dr. Denis Grant

Department of Pharmacology & Toxicology
University of Toronto

Use of mouse models to study mechanisms of chemical-induced liver damage and cancer

Denis Grant received his B.Sc. in Biochemistry from McMaster University in 1979 and his Ph.D. in Pharmacology from the University of Toronto in 1986, with a focus in drug metabolism and pharmacogenetics under the supervision of Werner Kalow. Following a postdoctoral fellowship in molecular pharmacogenetics with Urs Meyer at the Biozentrum of the University of Basel, Switzerland, he was appointed as a Scientist in the Research Institute of the Hospital for Sick Children in 1989, and as an Assistant Professor in the Departments of Pharmacology, Pediatrics and Pharmaceutical Sciences at the University of Toronto. In 1999 he took a position as Senior Director of Pharmacogenetics at Orchid Biosciences in Princeton, New Jersey, and in 2002 he returned to the University of Toronto to become Chair of the Department of Pharmacology & Toxicology from 2002 to 2012. He is currently a Professor in Pharmacology & Toxicology at the University of Toronto.
Dr. Grant's early research career focused on the study of interindividual variation in drug and chemical response and toxicity, including the first studies on the pharmacogenetics of caffeine metabolism and the elucidation of molecular mechanisms and toxic consequences of acetylation polymorphisms in human populations and animal models. His more recent research has utilized genetically modified mouse models, cell culture systems and biochemical methods to investigate mechanisms of acute and chronic cellular toxicity, gene dysregulation, transformation and tumorigenesis associated with exposure to aromatic amine, nitrosamine and polycyclic aromatic hydrocarbon toxicants. Dr. Grant has over 100 peer-reviewed articles, books and book chapters to his credit, and has been an invited speaker at over 100 national and international conferences and venues.


May 30th, 2018
3:00 - 4:00pm
School of Medicine, Room 132A

Reception to follow 4:30 - 6:00 pm
University Club