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Dr. Wayne Yokoyama

Event Start: Apr 17, 2019 1:00 pm
Location: School of Medicine, 132A


Wayne Yokoyama, M.D.
Sam J. and Audrey Loew Levin Professor
Rheumatology Division
Washington University Medical Center
St. Louis, MO



Innate lymphoid cells and uterine natural killer cells

Abstract
Innate lymphoid cells (ILCs) have been recently recognized to constitute a group of lymphocytes without rearranged antigen receptors that produce pro-inflammatory cytokines. Natural killer (NK) cells constitute charter members of ILCs, originally classified with group 1 ILCs (ILC1s), but recent evidence suggest they form a distinct lineage. Moreover, we and others have described tissue-resident NK cells that form distinct lineages from conventional NK cells and ILCs. How NK cells found in the virgin and pregnant uterus are related to the aforementioned cell types will be discussed.
Bio
Dr. Yokoyama is the Sam J. Levin and Audrey Loew Levin Chair Professor of Arthritis Research, and Professor of Medicine and of Pathology and Immunology at Washington University School of Medicine in St. Louis, Missouri. He also directs the Medical Scientist Training Program (MSTP), the largest integrated MD-PhD program in the country, and is Associate Director of the Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs (CHiiPs).
Dr. Yokoyama received his MD from the University of Hawaii. Following clinical training in internal medicine and rheumatology at the University of Iowa, he received postdoctoral research training at Iowa and at the National Institutes of Health. He previously served on the faculty of University of California, San Francisco and Mount Sinai (NY). In 1995, he was recruited to Washington University to become Chief of Rheumatology and in 2007, he became Director of the MSTP.
Dr. Yokoyama’s laboratory is credited with seminal discoveries regarding the molecular basis for natural killer (NK) cell function including discovery of the NK gene complex and of inhibitory receptors for MHC class I molecules that account for the “missing-self” hypothesis. His awards include the Novartis Prize for Basic Immunology, the top prize in the field of immunology; the Lee C. Howley Sr. Prize for Research in Arthritis, the top prize in arthritis research; and election to the National Academy of Sciences, the National Academy of Medicine, and American Academy of Arts and Sciences.
In 2017-18, he served as President of the American Association of Immunologists, the world’s largest society of professional immunologists.

Wednesday, April 17th, 2019
1:00 - 2:00 pm
School of Medince, Room 132A