Dana Philpott Dept. of Immunology University of Toronto
Regulation of innate immune signaling
NOD-like receptors (NLRs) comprise a family of innate immune pattern recognition receptors that are expressed in the cytoplasm of cells and respond to both microbial and danger signals. NLRs activate NF-kB driven pathways and also can form inflammasomes to result in the production and secretion of IL-1b and IL-18. Little is known how these pathways are regulated. Our laboratory has recently explored the contribution of cell stress pathways in regulating innate immune signaling. I will discuss our findings of how one of these pathways regulates complex formation to lead to the proper activation of inflammatory cytokines.