BCHM410/BMED810 - Protein Structure and Function

Course Description:

Theories and applications of protein structure determination techniques will be taught. The main focus is on NMR and X-ray crystallgroaphy. The course will also cover interpretation and applications of protein 3-D structure, structure-function relationships, structural classification, structural genomics, protein folding, structure-based drug design.  

Students (in groups) will be given the opportunities to present and discuss relevant research papers throughout the semester.

Course Objectives:
The main goal of this course is to help the students to integrate what they have learned in the Biochemistry / Life Sciences undergraduate programs to have a better appreciation of how proteins function and gain better understanding of structure-function relationship.
Textbook: There is no required textbooks for this course. All lecture notes in Power Point format will be available to students. Many of the lecture materials are generated from published research papers and review articles available in PubMed. If appropriate, references will be given in lecture notes.

Students will be evaluated by their performance in:

1) One mid-term examination (25%);

2) Student group presentations/discussions which also include questions and answers (25%);

3) Final examination (50%).

Total 100%.

Grading Method:
Queen’s Official Grade Conversion Scale

Grade  Numerical Course Average (Range)

A+            90-100

A              85-89

A-             80-84

B+            77-79

B              73-76

B-             70-72

C+            67-69

C              63-66

C-             60-62

D+            57-59

D              53-56

D-             50-52

F              49 and below

Expectations: Students are expected to attend all the lectures, participate in group presentations, collaborate with group members in the preparation and presentation of talks. Since there is no textbook required, self-learning via PubMed in addition to lecture notes is highly encouraged.
Academic Integrity: Academic integrity is constituted by the five core fundamental values of honesty, trust, fairness, respect and responsibility (see www.academicintegrity.org). These values are central to the building, nurturing and sustaining of an academic community in which all members of thecommunity will thrive. Adherence to the values expressed through academic integrity forms a foundation for the "freedom of inquiry and exchange of ideas" essential to the intellectual life of the University (see the Senate Report on Principles and Priorities: http://www.queensu.ca/secretariat/policies/senateandtrustees/principlespriorities.html).
Students are responsible for familiarizing themselves with the regulations concerning academic integrity
and for ensuring that their assignments conform to the principles of academic integrity. Information on
academic integrity is available in the Arts and Science Calendar (see Academic Regulation 1
1), on the Arts and Science website (see http://www.queensu.ca/artsci/academics/undergraduate/academic-integrity), and from the instructor of this course. Departures from academic integrity include plagiarism, use of unauthorized materials, facilitation, forgery and falsification, and are antithetical to the development of an academic community at Queen's. Given the seriousness of these matters, actions which contravene the regulation on academic integrity carry sanctions that can range from a warning or the loss of grades on an assignment to the failure of a course to a requirement to withdraw from the university.


Zongchao Jia
Steven P. Smith

If you have any questions, comments or suggestions, contact Course Coordinator: Dr. Jia Zongchao

Last Updated: Sep, 11 2017