Anne Croy, DVM, Ph.D
- Emeritus Professor
- Botterell Hall 537
- Telephone: 613 533-2859
- E-Mail: firstname.lastname@example.org
Faculty BioDr Anne Croy, Tier 1 Canada Research Chair in Reproduction, Development and Sexual Function.
Professor, Department of Biomedical and Molecular Sciences
Dr. Croy’s laboratory is now closed. She will not be offering future volunteer or research training opportunities.
DVM (University of Guelph), Ph.D. (University of Toronto)
My research evaluates the functions, mechanisms of activation and lineage relationships of immune competent cell populations that home to the maternal-fetal interface during mammalian pregnancy. Of particular interest is the uterine Natural Killer lymphocyte, a mobile cell population that appears to promote changes to maternal arteries suppling the developing placentas. We conduct investigations using mice and women and create custom models involving adoptive transfer of lymphocytes, blastocysts and/or fetal trophoblast to immune deficient mice to advance basic understanding of this complex interface.
The role of immune cells in maternal hemodynamic changes over pregnancy, and in programming of the fetal cardiovascular system in normal and diabetic pregnancies are included in our assessments. Many women who experience pre-eclampsia during pregnancy are deficient in angiogenic factors, especially Placental Growth Factor (PGF), for weeks before developing clinical signs. From our studies of PGF deficient mice, we predicted that children born in a severe, preeclamptic pregnancy would have abnormal brain vascular development by MRI and combining the studies with anatomic and cognitive function testing protocols standardized by the NeuroDevNet Canadian Centers of Excellence program. The goals of our studies are to promote improved fetal and maternal health.
Sources of Research Funds: Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation and Canada Research Chairs Program, The Garfield Kelly Foundation and the Harry Botterell Foundation, Kingston General Hospital.
Last Modified: 2018-01-24