Selected Publications:

Wilson LS, Guo M, Umana MB, Maurice DH. Distinct phosphodiesterase 5A-containing compartments allow selective regulation of cGMP-dependent signalling in human arterial smooth muscle cells. Cell Signal. 2017 36:204-211.

Rampersad SN, Freitag SI, Hubert F, Brzezinska P, Butler N, Umana MB, Wudwud AR, Maurice DH. EPAC1 promotes adaptive responses in human arterial endothelial cells subjected to low levels of laminar fluid shear stress: Implications in flow-related endothelial dysfunction. Cell Signal. 2016 28:606-19.

Rampersad SN, Wudwud A, Hubert F, Maurice DH. Adaptive phenotypic modulation of human arterial endothelial cells to fluid shear stress-encoded signals: Modulation by phosphodiesterase 4D-VE-cadherin signalling. Cell Signal. 2016 28:741-8.

Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov. 2014 13:290-314.

Maurice DH. PDE8A runs interference to limit PKA inhibition of Raf-1. Proc Natl Acad Sci U S A. 2013 110:6248-9.

Wilson LS, Baillie GS, Pritchard LM, Umana B, Terrin A, Zaccolo M, Houslay MD, Maurice DH. A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J Biol Chem. 2011 286:16285-96.

Rampersad SN, Ovens JD, Huston E, Umana MB, Wilson LS, Netherton SJ, Lynch MJ, Baillie GS, Houslay MD, Maurice DH. Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. J Biol Chem. 2010 285:33614-22.