Selected Publications:

  1.    K. Nakatsu and R.J. Reiffenstein.  Increased receptor utilization:  Mechanism of cocaine potentiation.  Nature, 217: 1276-1277, 1968.

  2.    K. Nakatsu and G.I. Drummond.  Adenylate metabolism and adenosine formation in the heart.  Amer. J. Physiol., 223: 1119-1127, 1972.

78. G.S. Marks, J.F. Brien, K. Nakatsu and B.E. McLaughlin. Does carbon monoxide have a physiological function? Trends Pharmacol. Sci. 12: 185-188, 1991.148.    R.T. Kinobe, Y. Ji, Jason Z. Vlahakis, Roberto Motterlini, James F. Brien, Walter A. Szarek and Kanji Nakatsu.  Effectiveness of Novel Imidazole-dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells.  J. Pharmacol. Exp. Ther. 323:763-770,  2007.

149.    Roman G, Riley JG, Vlahakis JZ, Kinobe RT, Brien JF, Nakatsu K, Szarek WA. Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem. 2007 May 1;15(9):3225-34. Epub 2007 Feb 22.
150.    Stephane L Bourque, Marina Komolova, Kanji Nakatsu, Michael A Adams. The long-term circulatory consequences of perinatal iron-deficiency in male Wistar rats.  Hypertension 51: 154-159, 2007.

151.    Stephane L Bourque, Umar Iqbal, James Reynolds, Michael A Adams, Kanji Nakatsu* Perinatal iron-deficiency induces cognitive and locomotor behavioural changes in adult male, but not female rats.  J. Nutrition.  138:931-7, 2008.

152.    Dick E. Zoutman, B. Douglas Ford, Assil R. Bassili, Jarold L. Cosby, Kanji Nakatsu. Factors Affecting Antibiotic Decisions for Upper Respiratory Tract Infections I: A Survey of Family Physicians.   International Journal of Infection Control 4(1) 1-7, 2008.

153.    Dick E. Zoutman, B. Douglas Ford, Assil R. Bassili, Jarold L. Cosby, Kanji Nakatsu. Factors Affecting Antibiotic Decisions for Upper Respiratory Tract Infections II: A Survey of Patients.  International Journal of Infection Control (In press).

154.    J. Soong, MA Adams, K Nakatsu.  Acute depletion of heme by succinylacetone alters vascular responses but does not induce hypertension.  Can J Physiol Pharmacol 86: 613-619, 2008.

155.    RT Kinobe, RA Dercho, K Nakatsu. Inhibitors of the Heme Oxygenase—Carbon Monoxide System: On the Doorstep of the Clinic?, Can J Physiol Pharmacol 86: 577-599, 2008.

156.    M Komalova, SL Bourque, K Nakatsu, MA Adams. Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats.  International Journal of Obesity 32:1441-1444, 2008.

157.    Jason Z. Vlahakis, Maaike Hum, Mona N. Rahman, Zongchao Jia, Kanji Nakatsu and Walter A. Szarek, Synthesis and evaluation of imidazole–dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring.  Bioorg Med Chem.:2461-75, 2009.

158.    Mona N. Rahman, Jason Z. Vlahakis, Walter A. Szarek, Kanji Nakatsu,  Zongchao Jia. X-ray crystal structure of human heme oxygenase-1in complex with 1-(adamantan-1-yl)-2-(1h-imidazol-1-yl)ethanone: a common binding mode for imidazolebased heme oxygenase-1 inhibitors.  J. Med. Chem. 2008, 51, 5943–5952.

159.    Mona N. Rahman, Jason Z. Vlahakis, Dragic Vukomanovic, Walter A. Szarek, Kanji Nakatsu, and Zongchao Jia. X-ray Crystal Structure of Human Heme Oxygenase-1with (2R,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-[(1Himidazol-1-yl)methyl]-4[{(5-trifluoromethylpyridin-2-yl)thio}methyl]-1,3-dioxolane:A Novel, Inducible Binding Mode. J. Med. Chem. 2009, 52, 4946–4950.

160.    Mona N Rahman,  Jason Z Vlahakis, Gheorghe Roman, Dragic Vukomanovic, Walter A Szarek, Kanji Nakatsu, Zongchao Jia.    Structural Characterization of Human Heme Oxygenase-1 in Complex with Azole-based Inhibitors. J Inorg Biochem. 2010 Mar;104(3):324-30. Epub 2009 Oct 24. Review.PMID: 19917515

161.    Gheorghe Roman, Mona N. Rahman, Dragic Vukomanovic, Zongchao Jia, Kanji Nakatsu and Walter A. Szarek.  Heme Oxygenase Inhibition by  2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.  Chemical Biology & Drug Design 75: 68-90, 2010. PMID: 19954435

162.    Dragic Vukomanovic1, Brian McLaughlin1, Mona N. Rahman2, Jason Z. Vlahakis3, Gheorghe Roman3, James F. Brien1, Zongchao Jia2, Walter A. Szarek3, and Kanji Nakatsu1*  Recombinant Truncated and Microsomal Heme Oxygenase-1 and -2: Differential Sensitivity to Inhibitors.  Can J Physiol Pharmacol 2010 Apr;88(4):480-6. PMID: 20555417

163.    Stephane L Bourque, Michael A Adams, Kanji Nakatsu, Andrew Winterborn. Comparison of Buprenorphine and Meloxicam for Post-Surgical Analgesia; effect  on body weight, ambient locomotor activity and hemodynamic parameters.  J Am Assoc Lab Anim Sci. 2010;49(5):617-22.PMID: 20858364

164.    Stephane L Bourque†, Carling D Benjamin†, Michael A Adams, Kanji Nakatsu*.  Lack of Hemodynamic Effects of Extended Heme Synthesis Inhibition by Succinylacetone in Rats.  J Pharmacol Exp Ther 333: 290-296, 2010. PMID: 20071481

165.    Maaike Hum, Brian E McLaughlin, Gheorghe Roman, Jason Z Vlahakis, Walter A Szarek, Kanji Nakatsu.  The Effects of Azole-Based Heme Oxygenase Inhibitors on Rat Cytochromes P450 2E1 & 3A1/2 and Human Cytochromes P450 3A4 & 2D6. J Pharmacol Exp Ther. 2010 Sep 1;334(3):981-7. Epub 2010 May 25.PMID: 20501634

166.    Vlahakis JZ, Rahman MN, Roman G, Jia Z, Nakatsu K, Szarek WA.     Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition. J Pharmacol Toxicol Methods. 63(1):79-88, 2011. Epub 2010 Jun 4.]PMID: 20561893

167.    Roman G, Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA. Heme oxygenase inhibition by 1-aryl-2-(1h-imidazol-1-yl/1h-1,2,4-triazol-1-yl)ethanones and their derivatives. ChemMedChem. 2010 Sep 3;5(9):1541-55.PMID: 20652928

168.    Milne B,VanDenKerkhof  EG, Phelan R, Brien JF, Forkert L, Nakatsu K.  Does Carbon Monoxide Play a Role in Cigarette Smoke Addiction?  Addiction Research & Theory, e-published 2011 July 19.

169.    Rahman MN, Vlahakis JV, Vukomanovic D, Szarek WA, Nakatsu K and Jia Z. A “double-clamp” binding mode for human heme oxygenase-1 inhibition. PLoS ONE (In press).

170.    Dragic Vukomanovic, Brian McLaughlin, Mona N. Rahman, Walter A.Szarek, James F. Brien, Zongchao Jia, and Kanji Nakatsu.  Selective Activation of Heme Oxygenase-2 by Menadione.  Can J Physiol Pharmacol (In Press).

171.    Jason Z. Vlahakis, Carmen Lazar, Gheorghe Roman, Dragic Vukomanovic, Kanji Nakatsu, and Walter A. Szarek .  Heme oxygenase inhibition by α-(1H-imidazol-1-yl)-Ω-phenylalkanes: Effect of introduction of heteroatoms in the alkyl linker.  Chem Med Chem (In Press).

173.  Bourque SL, Nakatsu K, Adams MA.  Perinatal iron deficiency combined with a high fat diet causes obesity and cardiovascular dysregulation.  Endocrinology Endocrinology. 2012 Mar;153(3):1174-82. Epub 2011 Dec 30. PMID: 22210741.

176.    Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA.  Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): exploration of the effects of substituents at the N-1 position.  Bioorganic & Medicinal Chemistry 21: 6788-6795 (2013).

177.    Vukomanovic D, Rahman MN, Bilokin Y, Golub AG,  Brien JF, Szarek WA, Jia Z, Nakatsu K.  In vitro Activation of heme oxygenase-2 by menadione and its analogs.  Med Gas Res. 2014 Feb 18;4(1):4. doi: 10.1186/2045-9912-4-4.URL: