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R John MacLeod PhD
 R John MacLeod
Associate Professor
Contact Info
76 Stuart St. G
613-549-6666 x6552

Faculty Bio

Wnt signaling cascades initiated by the extracellular calcium-sensing receptor the intestinal (CaSR) We study how the extracellular calcium-sensing receptor (CaSR) mediates communi- cation between intestinal epithelia and sub-epithelial myofibroblasts. We are defining the signaling cascades of CaSR-mediated Wnt5a, Dkk-1, LRP6, and Ror2 that stimulate intestinal differentiation in health, colon cancer and intestinal inflammation.