Selected Publications

Chemically modified N-acylated hyaluronan fragments modulate proinflammatory cytokine production by stimulated human macrophages.

Babasola O, Rees-Milton KJ, Bebe S, Wang J, Anastassiades TP.

J Biol Chem. 2014 Sep 5;289(36):24779-91. doi: 10.1074/jbc.M113.515783.


Human acetyl-CoA:glucosamine-6-phosphate N-acetyltransferase 1 has a relaxed donor specificity and transfers acyl groups up to four carbons in length.

Brockhausen I, Nair DG, Chen M, Yang X, Allingham JS, Szarek WA, Anastassiades T.

Biochem Cell Biol. 2016 Apr;94(2):197-204. doi: 10.1139/bcb-2015-0115.


The modified amino sugar N-Butyryl Glucosamine fed to ovariectomized rats preserves bone mineral through increased early mineralization, but does not affect body composition

Tassos Anastassiades, Karen Rees-Milton, Wilma M. Hopman. FFHDl. Vol 7, No 10 (2017)


A novel quantitative approach to the measurement of abdominal aortic calcification as applied to the Canadian Multicenter Osteoporosis Study (CaMOS).

Grant M, Turner ME, Murray-Guenther J, Anastassiades T, Hopman WM, Adams SM, Jeronimo P, Nolan R, Adams MA, Holden RM.

Bone. 2017 Apr;97:201-208. doi: 10.1016/j.bone.2017.01.018


Hyaluronic acid derivatives

Patent number: 9644040, Date of Patent: May 9, 2017, Inventor: Tassos Anastassiades

Abstract: The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been substituted, and methods and uses thereof.


Method for increasing the bone mineral density and bone micro-architecture or connectivity of a mammal using N-acylated glucosamines

Patent number: 7429573, Date of Patent: Sept 30, 2008, Inventor: Tassos Anastassiades

Abstract: A method of treating a mammal for a purpose selected from the group consisting of (a) increasing bone mineral density (BMD), (b) treating low BMD, (c) preventing and treatment of low impact fractures, (d) treatment of high impact fractures; (e) treating osteoporosis; (f) modulating a growth factor that influences bone metabolism; and (g) improving bone micro-architecture or connectivity of bone; the method comprising administering to the mammal an effective amount of a N-acylated-2-glucosamine derivative of the general formula (I): wherein R is an alkyl radical of the general formula CnH2n+1 and n is selected from 2-12.