Jyh-Yeuan (Eric) Lee, Ph.D. Professeur adjoint / Assistant Professor Biochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology Faculté de médecine / Faculty of Medicine, Université d’Ottawa / University of Ottawa
“More than just ABC”
The ATP-binding cassette (ABC) transporters carry out substrate translocation across cell membranes by coupling the energy of ATP binding and/or hydrolysis. While the ATPase domain is highly conserved, recent structural studies of ABC transporters have shown diverse structural folds in the integral transmembrane domains. Our research lies in mechanistic understanding of membrane cholesterol transport by studying the structure-function relationship of ABC transporters. This seminar presentation will includes the following three objectives. 1) I will give an overview of the structural diversity of ABC transporters. 2) Using ABCG5/G8 as the primary model, I will describe the challenge and the findings from studying ABC cholesterol transporters. 3) I will discuss our working model and future directions to investigate membrane cholesterol transport by ABC transporters.