Five DBMS Researchers Awarded CIHR Funding
Seven members of the Faculty of Health Sciences, including five from Department of Biomedical and Molecular Sciences, have been awarded with a total of $5.76 million in funding from the Canadian Institute of Health Research (CIHR), Canada’s federal agency for funding health research. The CIHR Project Grants are designed to support researchers at any career stage build and conduct health-related research and knowledge translation projects. All seven grants have been awarded to successful applicants of the CIHR Spring 2020 Project Grant competition, the results of which can be viewed here https://cihr-irsc.gc.ca/e/52145.html
The successful DBMS researchers are: Dr. Andrew Craig, Dr. Nader Ghasemlou, Dr. Charles Graham, Dr. Martin Paré, and Dr. Lynne-Marie Postovit.
Dr. Andrew Craig is Associate Head Research in DBMS and a Principle Investigator at Queen’s Cancer Research Institute. His funded research program aims to improve responses of ovarian cancer to both chemotherapy and immunotherapy. Ovarian cancer is a leading cause of cancer-related deaths in Canadian women, and advances in ovarian cancer therapies are needed. Dr. Craig’s research will use advanced genetic and pharmacological tools to identify new combinations of therapies that improve therapy responses in ovarian cancer patients and identify fundamental mechanisms of tumour biology.
Dr. Nader Ghasemlou is an Assistant Professor in the Departments of Anesthesiology and Biomedical & Molecular Sciences, and Director of Queen’s Translational Research in Pain. His research is focused on better understanding neuro-immune interactions in post-operative pain. His recent work has found that immune cells in the skin produce specific signaling mediators that activate sensory neurons to cause pain. Additionally, he has determined that by blocking the receptors of these proteins, pain can be substantially reduced. Dr. Ghasemlou’s proposal will examine how these cells communicate with pain-sensing neurons, and to how this can be used to prevent and treat pain.
Dr. Charles Graham is a Professor in DBMS. His research is focused on the role of innate immune memory in the response to immunotherapy of bladder cancer. Bladder cancer is one of the most common cancers worldwide, and the immunotherapy used to treat bladder cancer involves the administration of bacteria, which cause the patients’ immune system to fight the cancer cells. Unfortunately, up to half of patients do not respond fully and the cancer returns. Dr. Graham and his team of co-investigators are conducting research that aims to better understand how this immunotherapy works and why some patients don’t respond well. This work would lead to the development of new bladder cancer treatment methods.
Dr. Martin Paré is a Professor in DBMS. His research aims to gain a comprehensive understanding of the effects of drugs used in mental disorders to modify cognitive function. Dr. Paré’s project will evaluate task performance and memory to investigate how drugs used in the treatment of ADHD can impact their function. Findings from this study will help to better understand the neural mechanisms that are dysfunctional in mental disorders and become impaired in aging.
Dr. Lynne-Marie Postovit is a Professor and Head of the Department of Biomedical & Molecular Sciences. Her research interests involve improving treatment options for cancers whose observable characteristics commonly revert to more generalized conditions or structures. These cancers no longer look like the tissue from which they arise, but rather look more like tissue in an embryo, and as a result have a very poor prognosis. Dr. Postovit’s CIHR-funded study will determine the extent to which this phenomenon is promoted by the loss of components of the SWI/SNF protein complex. In addition, it will determine how to target and kill cancers which undergo this process.