Research Showcase - Allingham/Craig/Evans labs
A multidisciplinary study published in the high impact journal JACS from the Allingham, Craig and Evans labs identifies synthetic analogs of the filamentous actin severing toxin Mycalolide B that reduce the invasiveness of metastatic cancer cells.
Cancer cell invasion and tumour metastasis are driven by the actin cytoskeleton
Actin severing activity of the macrolide toxin Mycalolide B has been retained in a simplified synthetic analog
New therapies targeting metastasis will be developed around delivery systems for the synthetic analogs targeting actin
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