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analogs of an actin toxin natural product with anti-cancer activity

Research Showcase - Allingham/Craig/Evans labs

A multidisciplinary study published in the high impact journal JACS from the Allingham, Craig and Evans labs identifies synthetic analogs of the filamentous actin severing toxin Mycalolide B that reduce the invasiveness of metastatic cancer cells. 

Highlights

Cancer cell invasion and tumour metastasis are driven by the actin cytoskeleton

Actin severing activity of the macrolide toxin Mycalolide B has been retained in a simplified synthetic analog

New therapies targeting metastasis will be developed around delivery systems for the synthetic analogs targeting actin

 

Get the full story here: 

https://pubs.acs.org/doi/10.1021/jacs.0c12404