My research interests are summarized below: (i) Mechanistic studies to understand the development of cardiac hypertrophy In collaboration with Drs. Stephen Pang (DBMS) and Amer Johri (Cardiology), we are currently determining the mechanism of gender-related heart disease and cardiac hypertrophy in post-menopausal females. Our studies will focus the vasoactive and immune mechanisms related to vascular plaque and heart disease. (ii) Another area of interest examines the developmental origins of human diseases. In collaboration with Dr. Stephen Pang we will examine how the in-utero maternal environment affects the outcome of the offspringÕs cardiovascular health in later life. (iii) Development of engineered articular cartilage Ð In collaboration with Drs. David Bardana (Orthopedic Surgery), Andrew Winterborne (Health Sciences), James Stewart and Manuela Kunz (Computing), Mark Hurtig (Ontario Veterinary College, Univ. of Guelph), Stephen Waldman (Mechanical Engineering) and Stephen Pang, we are studying the molecular mechanisms that occur during mechanical stimulation of engineered articular cartilage tissue. Synthetic cartilage is constructed in a bioreactor from a small number chondrocytes isolated from biopsy samples. This technology aims at synthesizing cartilage, suitable for autologous implantation, to repair damaged areas of the joint. (vi) With the collaborations of Drs. Will King (Epidemiology), Janet Ashbury (Epidemiology), Stephen Vanner (GIDRU) and Sherry Taylor (Pathology, Dalhousie Univ.) and Stephen Pang we are evaluating the potential of using measurements of LINE-1 DNA methylation as a marker for a personÕs propensity to develop colorectal cancer.
My research program focuses on:
(i) Mechanistic studies on the development of cardiac hypertrophy - In collaboration with Drs. Stephen Pang (Anatomy and Cell Biology), we are currently determining the mechanism of gender-related cardiac hypertrophy development in post-menopausal women. Studies on the cardioprotective effect of ANP are done in conjunction with Drs. Pang and Melo (Physiology).
(ii) Biocompatibility of engineered materials - With Drs. Brian Amsden (Chemical Engineering) and Pang, we are currently examining the regenerative capabilities of long-term delivery of hepatocyte growth factor to the heart following a heart attack. (iii) Development of engineered articular cartilage - With Dr. Stephen Waldman (Mechanical Engineering) and Pang, we are studying the molecular mechanisms that occur during mechanical stimulation of engineered articular cartilage tissue.
1. Sangaralingham, SJ; MY Tse, SC Pang. Estrogen protects against the development of salt-sensitive cardiac hypertrophy in heterozygous proANP gene disrupted mice. Journal of Endocrinology; Accepted April 16, 2007. (In press)
2. O’Tierney, PF, MY Tse, SC Pang. Elevated renal norepinephrine in proANP gene-disrupted mice is associated with increased tyrosine hydroxylase expression in sympathetic ganglia. Regulatory Peptides; Accepted Epub: April 11, 2007. (In Press)
3. Liu, X.-L., JA Simpson, KR Brunt, CA Ward, SRR Hall, RT Kinobe, V Barrette, MY Tse, SC Pang, AS Pachori, VJ Dzau, KO Ogunyankin, LG Melo. Pre-emptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function one-year after acute myocardial infarction. American Journal of Physiology, Accepted Epub: Feb 23 2007 (In Press)
4. Amsden, BG; MY Tse; ND Turner; DK Knight; SC Pang. In vivo degradation behavior of photo-cross-linked star-poly(epsilon-caprolactone-co-D,L-lactide) elastomers.
Biomacromolecules 7(1): 365-372, 2006.
5. Brunt, KR, KK Fenrich, G Kiani, MY Tse, SC Pang, CA Ward, LG Melo. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arteriosclerosis, Thrombosis and Vascular Biology 26(9):2027-2034, 2006.