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Xenobiotic Disposition and Toxicity </h2> <div class=""> <div class="content block-content"> <div class="breadcrumb-links"> <div class="content-inner"> <nav class="breadcrumb " role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/index.php/">Home</a> <span class=""> / </span> </li> <li> </li> <li> PHAR 416 - Xenobiotic Disposition and Toxicity </li> <li></li> </ol> </nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div role="main" class="main main-page"> <div class="clearfix"></div> <div class="clearfix"></div> <div class="clearfix"></div> <div id="content" class="content content-full"> <div class="container"> <div class="content-main-inner"> <div class="row"> <div id="page-main-content" class="main-content col-xs-12 col-md-8 sb-r "> <div class="main-content-inner"> <div class="content-main"> <div class="region region-content"> <div id="block-gavias-financial-content" class="block block-system block-system-main-block no-title"> <div class="content block-content"> <!-- Start Display article for teaser page --> <!-- Start Display article for detail page --> <article id="research_project"> <div class="team-single-page"> <div class="team-info"> <div class="row"> <div class="col-lg-12 col-sm-12 col-xs-12"> <div class="team-image"></div> <div class="team-name clearfix"> <div class="name"> <h2 class="node__title" style="text-transform: none;"><span class="field field--name-title field--type-string field--label-hidden">PHAR 416 - Xenobiotic Disposition and Toxicity</span> </h2> </div> </div> </div> </div> <div class="row"> <div class="col-lg-3 col-sm-3 col-xs-12" > <div class="research_section"><i class="fa fa-calendar" aria-hidden="true"></i> Fall 2025 (On-Campus)</div> <div class="research_section"><i class="fa fa-info-circle" aria-hidden="true"></i> Year 4 </div> <div class="research_section"><i class="fa fa-clock-o" aria-hidden="true"></i> 9-10 hours/week</div> <div class="research_section"><i class="fa fa-signal" aria-hidden="true"></i> 3 units</div> <div class="research_section" > <div class="field__label">Available</div> <div> <i class="fa fa-university" aria-hidden="true"></i> On-Campus Course</div> </ul> </div> <div class="research_section"></div> </div> <div class="col-lg-9 col-sm-9 col-xs-12"> <div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An advanced study of chemical disposition and toxicity. Topics include toxicokinetics, biotransformation, metabolite-mediated toxicity, free radicals, the mechanism of action of toxicants, effects of toxicants on organ systems and a detailed examination of selected toxic agents.</p> <p><em>NOTE</em> BCHM, BIOL and BMCO students should contact the department for permission to register in this course.</p> </div> </div> </div> <div class="col-lg-12 col-sm-12 col-xs-12" > <hr /> <div class="gsc-accordion"> <div class="panel-group skin-dark collapse-all" id="accordion-830" role="tablist" aria-multiselectable="true"> <div class="panel panel-default"> <div class="panel-heading" role="tab"> <h4 class="panel-title"> <a role="button" data-toggle="collapse" class="" data-parent="#accordion-830" href="#accordion-830-1" aria-expanded="true"> Prerequisites </a> </h4> </div> <div id="accordion-830-1" class="panel-collapse collapse in" role="tabpanel"> <div class="panel-body"> <p>Level 4 or above and registration in a LISC/BCHM Major or Specialization, ELSC Specialization, or BHSc program, and a CGPA of 2.5 or higher and (PHAR 370/3.0 or BCHM 310/9.0 or BCHM 316/3.0).</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" role="tab"> <h4 class="panel-title"> <a role="button" data-toggle="collapse" class="" data-parent="#accordion-830" href="#accordion-830-7" aria-expanded="true"> Evaluations </a> </h4> </div> <div id="accordion-830-7" class="panel-collapse collapse in" role="tabpanel"> <div class="panel-body"> <p>Problem sets (2): 12.5% each, 25% of final grade</p> <p>Mid-term examination (in class): 25% of final grade</p> <p>Final examination (3 hours): 50% of final grade</p> <p><em>All exams will be a combination of multiple-choice and short-answer/essay formats, and will cover material from all lectures.</em></p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" role="tab"> <h4 class="panel-title"> <a role="button" data-toggle="collapse" class="" data-parent="#accordion-830" href="#accordion-830-9" aria-expanded="true"> Time Commitment </a> </h4> </div> <div id="accordion-830-9" class="panel-collapse collapse in" role="tabpanel"> <div class="panel-body"> <p>3 hours in class per week. Students can expect to spend approximately 10 hours per week on this course.</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" role="tab"> <h4 class="panel-title"> <a role="button" data-toggle="collapse" class="" data-parent="#accordion-830" href="#accordion-830-10" aria-expanded="true"> Textbooks and Materials </a> </h4> </div> <div id="accordion-830-10" class="panel-collapse collapse in" role="tabpanel"> <div class="panel-body"> <h4>Recommended Textbook:</h4> <p><em>Casarett and Doull's Toxicology</em>, 8th edition: C.D. Klaasen (ed)., McGraw-Hill, 2013</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" role="tab"> <h4 class="panel-title"> <a role="button" data-toggle="collapse" class="" data-parent="#accordion-830" href="#accordion-830-13" aria-expanded="true"> Grading Method </a> </h4> </div> <div id="accordion-830-13" class="panel-collapse collapse in" role="tabpanel"> <div class="panel-body"> <table align="left" border="0" cellpadding="1" cellspacing="1"> <thead> <tr> <th scope="col">Letter Grade</th> <th scope="col">Percentage</th> </tr> </thead> <tbody> <tr> <td>A+</td> <td>90-100</td> </tr> <tr> <td>A</td> <td>85-89.9</td> </tr> <tr> <td>A-</td> <td>80-84.9</td> </tr> <tr> <td>B+</td> <td>77-79.9</td> </tr> <tr> <td>B</td> <td>73-76.9</td> </tr> <tr> <td>B-</td> <td>70-72.9</td> </tr> <tr> <td>C+</td> <td>67-69.9</td> </tr> <tr> <td>C</td> <td>63-66.9</td> </tr> <tr> <td>C-</td> <td>60-62.9</td> </tr> <tr> <td>D+</td> <td>57-59.9</td> </tr> <tr> <td>D</td> <td>53-56.9</td> </tr> <tr> <td>D-</td> <td>50-52.9</td> </tr> <tr> <td>F</td> <td>0-49.9</td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-lg-12 col-sm-12 col-xs-12 clearfix"> <div class="team-description"></div> </div> </div> </div> <!--<div class="node__content clearfix"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An advanced study of chemical disposition and toxicity. Topics include toxicokinetics, biotransformation, metabolite-mediated toxicity, free radicals, the mechanism of action of toxicants, effects of toxicants on organ systems and a detailed examination of selected toxic agents.</p> <p><em>NOTE</em> BCHM, BIOL and BMCO students should contact the department for permission to register in this course.</p> </div> <div class="clearfix text-formatted field field--name-field-academic-intergrity field--type-text-long field--label-above"> <div class="field__label">Academic Intergrity</div> <div class="field__item"><p><strong>Academic integrity</strong> is constituted by the five core fundamental values of honesty, trust, fairness, respect and responsibility (see <a href="http://www.academicintegrity.org">www.academicintegrity.org</a>). These values are central to the building, nurturing and sustaining of an academic community in which all members of the community will thrive. Adherence to the values expressed through academic integrity forms a foundation for the "freedom of inquiry and exchange of ideas" essential to the intellectual life of the University (see the Senate Report on Principles and Priorities: <a href="http://www.queensu.ca/secretariat/policies/senateandtrustees/principlespriorities.html">http://www.queensu.ca/secretariat/policies/senateandtrustees/principlespriorities.html</a>).</p> <p><br> Students are responsible for familiarizing themselves with the regulations concerning academic integrity<br> and for ensuring that their assignments conform to the principles of academic integrity. Information on<br> academic integrity is available in the Arts and Science Calendar (see Academic Regulation 1<br> <a href="http://www.queensu.ca/artsci/academic-calendars/2011-2012-calendar/academic-regulations/regulation-1">http://www.queensu.ca/artsci/academic-calendars/2011-2012-calendar/academic-regulations/regulation-1</a>), on the Arts and Science website (see <a href="http://www.queensu.ca/artsci/academics/undergraduate/academic-integrity">http://www.queensu.ca/artsci/academics/undergraduate/academic-integrity</a>), and from the instructor of this course. Departures from academic integrity include plagiarism, use of unauthorized materials, facilitation, forgery and falsification, and are antithetical to the development of an academic community at Queen's. Given the seriousness of these matters, actions which contravene the regulation on academic integrity carry sanctions that can range from a warning or the loss of grades on an assignment to the failure of a course to a requirement to withdraw from the university.</p> </div> </div> <div class="field field--name-field-asc-course field--type-boolean field--label-above"> <div class="field__label">ASC Course</div> <div class="field__item">Off</div> </div> <div class="clearfix text-formatted field field--name-field-assessments field--type-text-long field--label-above"> <div class="field__label">Evaluations</div> <div class="field__item"><p>Problem sets (2): 12.5% each, 25% of final grade</p> <p>Mid-term examination (in class): 25% of final grade</p> <p>Final examination (3 hours): 50% of final grade</p> <p><em>All exams will be a combination of multiple-choice and short-answer/essay formats, and will cover material from all lectures.</em></p> </div> </div> <div class="field field--name-field-course-degree field--type-entity-reference field--label-above"> <div class="field__label">Course Degree</div> <div class="field__items"> <div class="field__item"><a href="/index.php/taxonomy/term/44" hreflang="en">Undergraduate</a></div> </div> </div> <div class="field field--name-field-course-hours field--type-list-string field--label-above"> <div class="field__label">Course Hours</div> <div class="field__item">9-10 hours/week</div> </div> <div class="field field--name-field-course-location field--type-entity-reference field--label-above"> <div class="field__label">Course Location</div> <div class="field__items"> <div class="field__item"><a href="/index.php/taxonomy/term/53" hreflang="en">On-Campus Course</a></div> </div> </div> <div class="field field--name-field-course-offering field--type-entity-reference field--label-above"> <div class="field__label">Course Offering</div> <div class="field__items"> <div class="field__item"><a href="/index.php/taxonomy/term/55" hreflang="en">Fall</a></div> <div class="field__item"><a href="/index.php/taxonomy/term/75" hreflang="en">Fall On-Campus</a></div> </div> </div> <div class="field field--name-field-course-terms field--type-string field--label-above"> <div class="field__label">Course Term(s)</div> <div class="field__item">Fall 2025 (On-Campus)</div> </div> <div class="field field--name-field-course-units field--type-list-string field--label-above"> <div class="field__label">Course Units</div> <div class="field__item">3 units</div> </div> <div class="field field--name-field-course-year field--type-list-string field--label-above"> <div class="field__label">Course Year</div> <div class="field__item">Year 4</div> </div> <div class="clearfix text-formatted field field--name-field-grading-method field--type-text-long field--label-above"> <div class="field__label">Grading Method</div> <div class="field__item"><table align="left" border="0" cellpadding="1" cellspacing="1"> <thead> <tr> <th scope="col">Letter Grade</th> <th scope="col">Percentage</th> </tr> </thead> <tbody> <tr> <td>A+</td> <td>90-100</td> </tr> <tr> <td>A</td> <td>85-89.9</td> </tr> <tr> <td>A-</td> <td>80-84.9</td> </tr> <tr> <td>B+</td> <td>77-79.9</td> </tr> <tr> <td>B</td> <td>73-76.9</td> </tr> <tr> <td>B-</td> <td>70-72.9</td> </tr> <tr> <td>C+</td> <td>67-69.9</td> </tr> <tr> <td>C</td> <td>63-66.9</td> </tr> <tr> <td>C-</td> <td>60-62.9</td> </tr> <tr> <td>D+</td> <td>57-59.9</td> </tr> <tr> <td>D</td> <td>53-56.9</td> </tr> <tr> <td>D-</td> <td>50-52.9</td> </tr> <tr> <td>F</td> <td>0-49.9</td> </tr> </tbody> </table> </div> </div> <div class="field field--name-field-learning-tracks-tags field--type-entity-reference field--label-above"> <div class="field__label">Learning Tracks Tags</div> <div class="field__items"> <div class="field__item"><a href="/index.php/taxonomy/term/51" hreflang="en">Pharmacology and Toxicology (PHAR)</a></div> </div> </div> <div class="clearfix text-formatted field field--name-field-prerequisites field--type-text-long field--label-above"> <div class="field__label">Prerequisites</div> <div class="field__item"><p>Level 4 or above and registration in a LISC/BCHM Major or Specialization, ELSC Specialization, or BHSc program, and a CGPA of 2.5 or higher and (PHAR 370/3.0 or BCHM 310/9.0 or BCHM 316/3.0).</p> </div> </div> <div class="clearfix text-formatted field field--name-field-textbooks-and-materials field--type-text-long field--label-above"> <div class="field__label">Textbooks and Materials</div> <div class="field__item"><h4>Recommended Textbook:</h4> <p><em>Casarett and Doull's Toxicology</em>, 8th edition: C.D. Klaasen (ed)., McGraw-Hill, 2013</p> </div> </div> <div class="clearfix text-formatted field field--name-field-time-commitment field--type-text-long field--label-above"> <div class="field__label">Time Commitment</div> <div class="field__item"><p>3 hours in class per week. Students can expect to spend approximately 10 hours per week on this course.</p> </div> </div> </div>--> </div> </article> <!-- End Display article for detail page --> </div> </div> </div> </div> </div> </div> <!-- Sidebar Left --> <!-- End Sidebar Left --> <!-- Sidebar Right --> <div class="col-lg-4 col-md-4 col-sm-12 col-xs-12 sidebar sidebar-right theiaStickySidebar"> <div class="sidebar-inner"> <div class="region region-sidebar-right"> <div class="views-element-container block block-views block-views-blockcourses-block-4" id="block-views-block-courses-block-4"> <h2 class="block-title" ><span>Undergraduate Courses</span></h2> <div class="content block-content"> <div><div class="exposed-filter--custom gva-view view view-courses view-id-courses view-display-id-block_4 js-view-dom-id-cd459043d14f18f8f8b3302d77765f6b13a81461c363fcfbcc8ab9cba1152107"> <div class="view-filters"> <form class="views-exposed-form" data-drupal-selector="views-exposed-form-courses-block-4" action="/index.php/courses/undergraduate/phar-416-xenobiotic-disposition-and-toxicity" method="get" id="views-exposed-form-courses-block-4" accept-charset="UTF-8"> <div class="form--inline clearfix"> <div class="js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-title-research-all form-item-title-research-all"> <label for="edit-title-research-all">Search</label> <input placeholder="Search course title" data-drupal-selector="edit-title-research-all" type="text" id="edit-title-research-all" name="title-research-all" value="" size="30" maxlength="128" class="form-text" /> </div> <div class="js-form-item form-item js-form-type-select form-type-select js-form-item-focus form-item-focus"> <label for="edit-focus">Course Focus</label> <select data-drupal-selector="edit-focus" id="edit-focus" name="Focus" class="form-select"><option value="All" selected="selected">- Any -</option><option value="46">Anatomy and Cell Biology (ANAT)</option><option value="63">Biochemistry (BCHM)</option><option value="64">Cancer (CANC)</option><option value="65">Cardiorespiratory Sciences (CRSS)</option><option value="81">Discovery Lab (DISC)</option><option value="66">Drug Discovery and Human Toxicology (DDHT)</option><option value="70">Global and Population Health (GLPH)</option><option value="71">Health Sciences Research (HSCI)</option><option value="72">Interdisciplinary Studies (IDIS)</option><option value="67">Life Sciences (LISC)</option><option value="50">Microbiology and Immunology (MICR)</option><option value="68">Neuroscience (NSCI)</option><option value="80">Pathology and Molecular Medicine (PATH)</option><option value="51">Pharmacology and Toxicology (PHAR)</option><option value="69">Physiology (PHGY)</option><option value="73">Reproduction and Development (REPD)</option></select> </div> <div class="js-form-item form-item js-form-type-select form-type-select js-form-item-offering form-item-offering"> <label for="edit-offering">Term Offered</label> <select data-drupal-selector="edit-offering" id="edit-offering" name="offering" class="form-select"><option value="All" selected="selected">- Any -</option><option value="55">Fall</option><option value="75">Fall On-Campus</option><option value="74">Fall Online</option><option value="56">Winter</option><option value="77">Winter On-Campus</option><option value="76">Winter Online</option><option value="58">Spring</option><option value="78">Spring Online</option><option value="79">Spring On-Campus</option></select> </div> <div data-drupal-selector="edit-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-actions"><input data-drupal-selector="edit-submit-courses" type="submit" id="edit-submit-courses" value="Apply" class="button js-form-submit form-submit" /> </div> </div> </form> </div> <div class="view-content"> <div class="view-content-wrap"> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-100-anatomy-human-body">ANAT 100 Anatomy of the Human Body</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-101-introductory-human-anatomy">ANAT 101 - Introductory Human Anatomy</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-215-principles-human-morphology-i">ANAT 215 - Principles of Human Morphology I</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-216-principles-human-morphology-ii">ANAT 216 - Principles of Human Morphology II</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-309-bmed-831-functional-histology">ANAT 309 / BMED 831 - Functional Histology</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-312-bmed-812-functional-neuroanatomy">ANAT 312 / BMED 812 - Functional Neuroanatomy</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-315-functional-human-anatomy-i">ANAT 315 - Functional Human Anatomy I</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-316-functional-human-anatomy-ii">ANAT 316 - Functional Human Anatomy II</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-380-clinically-relevant-human-anatomy">ANAT 380 Clinically Relevant Human Anatomy</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-391-introduction-cadaveric-dissection">ANAT 391 Introduction to Cadaveric Dissection</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-409-selected-topics-histology">ANAT 409 - Selected Topics in Histology</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-417-bmed-817-mammalian-embryonic-development">ANAT 417 / BMED 817 - Mammalian Embryonic Development</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-471-bmed-817-human-embryology">ANAT 471 / BMED 817 Human Embryology</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-499-research-project-anatomy-cell-biology">ANAT 499 - Research Project in Anatomy & Cell Biology</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/anat-599-research-inquiry-anatomy">ANAT 599 Research Inquiry in Anatomy</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/bchm-102-introduction-biochemistry">BCHM 102 - Introduction to Biochemistry</a></div> </div> </div> </div></span></div> </div> <div class="item"> <div class="views-field views-field-nothing"><span class="field-content"><div class="portfolio-v2 isotope-item "> <div class="portfolio-content"> <div class="content-inner"> <div class="title"> <a href="https://dbms.queensu.ca/index.php/courses/undergraduate/bchm-218-molecular-biology">BCHM 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