Research Interests
Cells constantly adjust their metabolism to survive environmental and physiological stress. Our research explores how mitochondria function as stress-sensing organelles that help cells detect metabolic imbalance and activate adaptive responses. We investigate how changes in mitochondrial structure and function generate signals that reprogram cellular metabolism and promote survival under stress. These adaptive pathways are particularly important in cancer, where tumor cells rely on mitochondrial stress signaling to maintain metabolic resilience and persist during therapy. By understanding how mitochondrial stress responses are controlled, including mechanisms such as mitophagy that maintains mitochondrial quality, we aim to uncover new vulnerabilities that can be targeted to limit cancer cell survival.
Please see the Chan lab website for our story and research opportunities.