Dr. Pieter Dorrestein

Professor, University of California, San Diego
Skaggs School of Pharmacy and Pharmaceutical Sciences
Departments of Pharmacology and Pediatrics
Director, Collaborative Mass Spectrometry Innovation Center
Co-Director, Institute for Metabolomics Medicine

Connecting the World’s Mass Spectrometry Data to Understand the Chemistry of Life – a Big Data Strategy

Imagine if we could figure out the chemical composition of any sample and understand their relationships of the molecules to all other samples in seconds – akin to a Google search but instead of using a text we use mass spectrometry information. This is now beginning to be possible. The foundation for such infrastructure is being created through community wide knowledge capture and analysis tool development. In this lecture I will discuss the steps we have taken with building such community tools. This infrastructure is now used by 78,000 people worldwide. I will showcase how world-wide users are applying these tools in understanding the role of the microbiome in health and disease via reuse of public data, including non-clinical data. We have processed 100,000s of datasets and from this I will show representative examples associated with ecological questions, early therapeutic discovery, disease, sleep deprivation, personal care, malnutrition but also several single patient case studies, including a single patient phage therapy treatment but also how useful it is to enable rapid turn around of the analysis in a clinical setting.

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Effective immediately, all PhD Oral Examinations will be OPEN.  The examination may be switched to CLOSED for substantive reasons only, such as protection of sensitive data or major disability issues.  If a student wishes to have a CLOSED examination, they must apply to the Associate Dean of Graduate Students (Dr. Kim McAuley) for permission.

All PhD examinations in DBMS will be announced on the DBMS website, in addition to the Gazette.  Students are encouraged to attend theses examinations in order to gather an understanding of the process and to support their peers.

Room bookings do not need to take into consideration the audience size.  It is up to the Chair to decide how many bodies the room may accommodate at the time of the examination.  All audience members will be asked to vacate the room when the Candidate is asked to leave so that the confidential nature of the examiners’ discussion can be maintained.

Students undergoing MSc Oral Examinations are encouraged to consider an OPEN format, but should consult with their supervisor and may decide upon a CLOSED format without any penalty.  All examinations will be announced on the DBMS website.

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