Lab website: Coming soon.

Academic Experience

2015-2020: CIHR and CVN Postdoctoral Fellow (Stephen Archer), Department of Medicine, Queen’s University 

2009-2014: PhD in Molecular & Cellular Pathology (Scott Ballinger), Department of Pathology, University of Alabama at Birmingham

2006-2008: MPS in Forensic Science (Robert Shaler), Eberly College of Science, The Pennsylvania State University

2002-2006: B.Sc. (Hons.) in Applied Bio-Molecular Science (Carney Matheson), Faculty of Science & Environmental Studies, Lakehead University

Research Interests

My laboratory studies cardiovascular and cardiometabolic diseases. Using in vitro and in vivo preclinical models, we investigate the role of mitochondrial genetics and organelle structure in the aetiology and pathophysiology of these complex pathologies.

Our lab website is currently under construction – please check back soon.

Publications

2020

Theilmann A, Hawke L, Hilton L, Whitford M, Cole D, MacKeil J, Dunham-Snary KJ, Mewburn J, James P, Maurice D, Archer SL, Ormiston M. Endothelial BMPR2 loss drives a proliferative response to BMP9 in pulmonary arterial hypertension. ATVB. 2020; accepted.

DasGupta A, Wu D, Tian L, Xiong PY, Dunham-Snary KJ, Chen KH, Alizadeh E, Motamed M, Potus F, Hindmarch CCT, Archer SL. Mitochondria n the pulmonary vasculature in heath and disease: oxygen-sensing, metabolism and dynamics. Compr Physiol. 2020 Mar 127;10(2):713-765.

2019

Dunham-Snary KJ, Archer SL. Response by Dunham-Snary and Archer to Letter Regarding Article, “Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction”.Circ Res. 2019 Sep 27;125(8):e35-e36.

Dunham-Snary KJ, Wu D, Sykes EA, Potus F, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL. Ndufs2, a core subunit of mitochondrial complex I, is essential for acute oxygen-sensing and hypoxic pulmonary vasoconstriction. Circ Res. 2019 Jun 7;124(12): 1727-1746.

Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL. Biventricular increases in mitochondrial fission mediator (MiD51) and proglycolytic pyruvate kinase (PKM2) isoform in experimental group 2 pulmonary hypertension: novel mitochondrial abnormalities. Front Cardiovasc Med. 2019 Jan 25;5:195.

2018

Dunham-Snary KJ, Sandel MW, Sammy MJ, Westbrook DG, Xiao R, McMonigle RJ, Ratcliffe, WF, Penn A, Young ME, Ballinger SW. Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo. EBioMedicine. 2018 Oct;36:316-328.

Potus F, Hindmarch CCT, Dunham-Snary KJ, Stafford J, Archer SL. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.Int J Mol Sci. 2018 19(9):2730.

Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Mewburn JD, Wu D, Dunham-Snary KJ, Theilmann A, Jing ZC, Hindmarch C, Ormiston M, Archer SL. Epigenetic dysregulation of the Drp1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications. Circulation. 2018 Jul 17;138(3):287-304.

2017

Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary KJ, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med. 2017 Apr;95(4):381-393.

Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary KJ, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. MicroRNA-138 and MicroRNA-25 down-regulate mitochondrial calcium uniporter, causing the pulmonary arterial hypertension’s cancer phenotype. Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529.

Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LR, Mewburn JD, Parlow JL, Archer SL. Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine. Chest. 2017 Jan;151(1):181-192.

2016

King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary KJ, Oliva CR, Griguer CE, Bailey SM. The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease. Redox Biol. 2016 Oct;9:188-197.

Krzywanski DM, Moellering DR, Westbrook DG, Dunham-Snary KJ, Brown J, Bray AW, Feeley KP, Sammy MJ, Smith MR, Schurr TG, Vita JA, Ambalavanan N, Calhoun D, Dell'Italia L, Ballinger SW. Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet. 2016 Feb;9(1):26-36.

Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL. A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus. Pflugers Arch. 2016 Jan;468(1):43-58.

2015

Dunham-Snary KJ, Ballinger SW. GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science. 2015 Sep 25;349(6255):1449-50.

2014

Dunham-Snary KJ, Sandel MW, Westbrook DG, Ballinger SW. A method for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biol. 2014 Apr 18;2:656-60.

2013

Dunham-Snary KJ, Ballinger SW. Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility. Free Radic Biol Med. 2013 Dec;65:1229-37.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW. Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochem J. 2013 Oct 15;455(2):157-67. Erratum in: Biochem J. 2013 Oct 1;455(1):147.

2011

Krzywanski DM, Moellering DR, Fetterman JL, Dunham-Snary KJ, Sammy MJ, Ballinger SW. The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest. 2011 Aug;91(8):1122-35.

Lab Members

The Dunham-Snary Lab will soon be actively recruiting graduate students with backgrounds in cellular and/or molecular biology, life sciences, and other medical and health-related fields. Please check back here and at the lab’s website (coming soon) for details regarding upcoming available positions.