Skip to main content
Maurice lab define reciprocal regulation of cAMP signaling and calcium channels

Research Showcase - Don Maurice

A recent study from recent PhD graduate Paulina Brzezinska in Don Maurice’s lab was published in JBC and defines reciprocal regulation of store-operated calcium channels and cyclic AMP signaling networks in arterial smooth muscle cells,

Highlights

 1) Phosphodiesterase PDE1C-mediated cAMP hydrolysis is THE "trigger" that reverses PKA-mediated inhibition of SOCE through Orai1

 2) This mechanisms allows dynamic linking between SOCE and Ca2+-dependent regulation of cAMP synthesis at the leading edges of migrating cells.

 

Get the full story here: 

https://www.jbc.org/article/S0021-9258(21)00386-0/fulltext