Research Showcase - Don Maurice
A recent study from recent PhD graduate Paulina Brzezinska in Don Maurice’s lab was published in JBC and defines reciprocal regulation of store-operated calcium channels and cyclic AMP signaling networks in arterial smooth muscle cells,
1) Phosphodiesterase PDE1C-mediated cAMP hydrolysis is THE "trigger" that reverses PKA-mediated inhibition of SOCE through Orai1
2) This mechanisms allows dynamic linking between SOCE and Ca2+-dependent regulation of cAMP synthesis at the leading edges of migrating cells.
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