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Ghasemlou lab report on an improved model to study chronic pain in a mouse model of multiple sclerosis

Research Showcase - Nader Ghasemlou

Lead author Julia Segal (DBMS PhD candidate) reports the latest from Nader Ghasemlou's lab on how experimental autoimmune encephalomyelitis (EAE) models can be improved to study chronic pain. This is a major issue for patients with multiple sclerosis (MS), and this research will help inform on MS treatments in the future.

Highlights

•There are few effective therapies for those living with chronic MS pain.

•The induced model of disease in mice (EAE) appears to not exhibit pain hypersensitivity.

•We show that EAE outcomes are dependent on dose of pertussis toxin (PTX) used.

•Using a lower PTX dose allows for longitudinal pain hypersensitivity testing.

•Demyelination and neuroinflammation are still present using this lower dose.

 

Get the full story here https://doi.org/10.1016/j.bbi.2020.07.010