The research program of Dr. Stephen Pang is on the structure and function of the cardiovascular system in health and disease. His current research focus is on the design of gene therapies for the treatment of myocardial infarction (MI or heart attack). Using atrial natriuretic peptide (ANP) as a cardioprotective molecule, Dr. PangÕs laboratory is designing a new gene construct in order to protect the heart immediately following MI. Collaborations with Drs. Amer Johri (Cardiology), Albert Jin (Neurology), and David Andrew, Dr. PangÕs laboratory is studying the link between abnormal atrial natriuretic peptide expression, heart attack and stroke. Drs. Stephen Waldman (Mechanical Engineering), Davide Bardana (Orthopedic Surgery), James Stewart and Manuela Kunz (Computing), Mark Hurtig (Ontario Veterinary College, Univ. of Guelph), Andrew Winterborn (Health Sciences) and Pang are current working on methods of producing engineered articular cartilage for implantation and joint repair. With the collaborations of Drs. Will King, Janet Ashbury (Epidemiology), Stephen Vanner (GIDRU) and Sherry Taylor (Pathology, Dalhousie Univ.), Yat Tse, the Pang lab has established a method of quantifying LINE-1 DNA methylation and applying it in an epidemiological study to screen colorectal cancer.
The research program of Dr. Stephen Pang is on the structure and function of the cardiovascular system in health and disease. His current research focus is on the design of gene therapies for the treatment of myocardial infarction (MI or heart attack). Using atrial natriuretic peptide (ANP) as a cardioprotective molecule, Dr. Pang’s laboratory is designing a new gene construct in order to protect the heart immediately following MI. With the collaboration of Drs. Yat Tse, Luis Melo and Christopher Ward (Physiology), Dr. Pang is evaluating methods for developing a stem cell-based therapy for MI. Drs. Brian Amsden (Chemical Engineering) and Pang are developing a method of delivering hepatic growth factor as a means to treat MI. Drs. Stephen Waldman (Mechanical Engineering) and Pang are current working on methods of producing engineered articular cartilage for implantation and joint repair.
Sources of Research Funds: Heart and Stroke Foundation; Canadian Institutes of Health Research.
1. Armstrong, DWJ*; MY Tse; PG Wong*; NM Ventura*; JA Means; AM Johri; MF Matangi; SC Pang. Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction. Molecular and Cellular Biochemistry 391: 201-209, 2014.
2. King, WD; JE Ashbury; SA Taylor; MY Tse; SC Pang; JA Louw; SJ Vanner. A cross-sectional study of global DNA methylation and risk of colorectal adenoma. BioMed Central Cancer 14: 488-496, 2014.
3. Ventura, NM*; AY Jin; MY Tse; NT Peterson; RD Andrew; JD Mewburn; SC Pang. Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring. Molecular and Cellular Biochemistry 408(1-2): 223-233, 2015.
4. Ventura, NM*; TY Li**; MY Tse; RD Andrew; C Tayade; AY Jin; SC Pang. Onset and regression of pregnancy-induced cardiac alterations in gestationally-hypertensive dams: the role of the natriuretic peptide system. Biology of Reproduction 93(6): 142-149, 2015.
5. Li, TY*; MY Tse; SC Pangζ; CS McLellan; WD King; AM Johriζ. Sex differences of the natriuretic peptide polymorphism associated with angiographic coronary atherosclerosis. Cardiology Research 8(1): 1-6, 2017.
6. Chen, Z; AL Eadie; SR Hall; L Ballantyne; D Ademidun; MY Tse; SC Pang; LG Melo; CA Ward; KR Brunt. Assessment of hypoxia and TNF-alpha response by a vector with HRE and NF-kappaB response elements. Frontiers in Bioscience (Scholar Edition) 9: 46-54, 2017.
7. Whitney, GA; T Kean; RJ Fernandes; S Waldman; MY Tse; SC Pang; JM Mansour; JE Dennis. Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue engineered articular cartilage. Tissue Engineering Part A 0: 000-000, 2017.