PHAR 230 - Pharmacology for the Health Sciences
Lecture series on the following topics: principles of drug action, autonomic pharmacology, cardiovascular-renal pharmacology, neuropsychopharmacology, chemotherapy, drugs acting on the endocrine system, over-the-counter drugs, and therapeutic applications.
PHGY 210/6.0 or PHGY 214/6.0 or KNPE 225/3.0 or KINE 225/3.0.
No more than 3.0 units from PHAR 230/3.0; PHAR 270/3.0; PHAR 340/3.0
After completing this course, the student should be able to:
- Define and apply the following concepts regarding drug receptors to problems in pharmacology and patient care: receptor, drug, agonist, antagonist, partial agonist, affinity, efficacy.
- Differentiate and contrast the generic names of drugs with their trade names, and explain why use of generic names is preferable.
- List the mechanisms by which drugs can cross cell membranes.
- Describe the major mechanisms by which drugs are metabolized and the most important organs that are involved in drug metabolism.
- Describe the ways in which drugs can be removed from the body by the kidney, liver and lungs.
- Compare and contrast the beneficial and limiting features of the major routes of drug administration.
- Apply the following concepts regarding pharmacokinetics to the dose and dosage interval for drugs used in individual patients: half-life, rate constant of elimination, apparent volume of distribution, first-order kinetics, zero-order kinetics, clearance.
- List important prototype drugs from the topics listed in the lecture outlines.
- List the properties of each prototype drug with reference to:
- Mechanism of action.
- Potential adverse effects and outcome of specific drugs.
- Therapeutic uses.
- Important interactions with other drugs or solvents.
- List the factors that might alter the pharmacokinetics of each prototype with reference to:
- Age, gender, weight, and pregnancy.
- Hepatic and renal function.
- Drug-drug or drug-solvent interactions.
- Co-existing disease states.
Drug Literature Evaluation (D.L.E.) Project: 15%
Online Quizzes (best 3 of 4 will count): 10%
Mid-Term Examination (one hour, multiple-choice): 25%
Final Examination (three hours, multiple-choice): 50%
Lecture 3 hours per week
Tutorial 1 hour per week
There is no required textbook. A number of textbooks are available online to be used as reference material, e.g. B. Katzung, Basic and Clinical Pharmacology.