PHAR 416 - Xenobiotic Disposition and Toxicity
An advanced study of chemical disposition and toxicity. Topics include toxicokinetics, biotransformation, metabolite-mediated toxicity, free radicals, the mechanism of action of toxicants, effects of toxicants on organ systems and a detailed examination of selected toxic agents.
NOTE BCHM, BIOL and BMCO students should contact the department for permission to register in this course.
Level 4 or above and registration in a LISC/BCHM Major or Specialization, ELSC Specialization, or BHSc program, and a CGPA of 2.5 or higher and (PHAR 370/3.0 or BCHM 310/9.0 or BCHM 316/3.0).
Problem sets (2): 12.5% each, 25% of final grade
Mid-term examination (in class): 25% of final grade
Final examination (3 hours): 50% of final grade
All exams will be a combination of multiple-choice and short-answer/essay formats, and will cover material from all lectures.
3 hours in class per week. Students can expect to spend approximately 10 hours per week on this course.
Recommended Textbook:
Casarett and Doull's Toxicology, 8th edition: C.D. Klaasen (ed)., McGraw-Hill, 2013
| Letter Grade | Percentage |
|---|---|
| A+ | 90-100 |
| A | 85-89.9 |
| A- | 80-84.9 |
| B+ | 77-79.9 |
| B | 73-76.9 |
| B- | 70-72.9 |
| C+ | 67-69.9 |
| C | 63-66.9 |
| C- | 60-62.9 |
| D+ | 57-59.9 |
| D | 53-56.9 |
| D- | 50-52.9 |
| F | 0-49.9 |