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PHAR 416 - Xenobiotic Disposition and Toxicity

 Fall 2023
 Year 4
 9-10 hours/week
 3 units
On-Campus Course

An advanced study of chemical disposition and toxicity. Topics include toxicokinetics, biotransformation, metabolite-mediated toxicity, free radicals, the mechanism of action of toxicants, effects of toxicants on organ systems and a detailed examination of selected toxic agents.

NOTE BCHM, BIOL and BMCO students should contact the department for permission to register in this course.

Level 4 or above and registration in a LISC/BCHM Major or Specialization, ELSC Specialization, or BHSc program, and a CGPA of 2.5 or higher and (PHAR 370/3.0 or BCHM 310/9.0 or BCHM 316/3.0).

Problem sets (2):  12.5% each, 25% of final grade

Mid-term examination (in class):  25% of final grade

Final examination (3 hours):  50% of final grade

All exams will be a combination of multiple-choice and short-answer/essay formats, and will cover material from all lectures.

3 hours in class per week. Students can expect to spend approximately 10 hours per week on this course.

Recommended Textbook:

Casarett and Doull's Toxicology, 8th edition:  C.D. Klaasen (ed)., McGraw-Hill, 2013

Letter Grade Percentage
A+ 90-100
A 85-89.9
A- 80-84.9
B+ 77-79.9
B 73-76.9
B- 70-72.9
C+ 67-69.9
C 63-66.9
C- 60-62.9
D+ 57-59.9
D 53-56.9
D- 50-52.9
F 0-49.9