Walia | Biomedical and Molecular Sciences | School of Medicine | Queen's University

Jagdeep Walia

Jagdeep Walia

Position(s)

Professor

Contact Info

Jagdeep.Walia@kingstonhsc.ca

Paediatrics, Connell 4, Room 2-2422, Kingston General Hospital

613-548-2467

Research Interests

Our lab is focused on developing novel gene therapy approaches for inherited and acquired neurodegenerative disorders. Currently we are focusing on GM2-gangliosidoses (Tay-Sachs, Sandhoff diseases and AB variant) and use adeno-associated virus vector (AAV) system as a tool for gene transfer to the central and peripheral nervous system. Our research has already shown very encouraging results in a mouse model increasing the survival to almost 3 fold for this fatal disease. We are in process of testing multiple strategies to optimize the conditions with a target for clinical translation.

Our future directions include:

1) Understanding the basic biology of GM2 ganglioside and its effect on immune system; 2) Developing novel AAV vectors with in-built safety system;

3) Developing assays for hexosaminidase activity and peripheral blood markers for GM2 gangliosidoses; and

4) Understanding the inflammatory changes at gene expression and epigenetic level with and without AAV gene therapy treatment in GM2 gangliosidoses.

My clinical research involves study of genetics, epigenetics, metagenomics and metabolomics of Autism. I collaborate on many studies for inherited metabolic disorders.

Faculty

Abraham, Sheela, Associate Professor

Adams, Michael A., Professor

Allingham, John, Professor

Andrew, R. David, Professor

Banfield, Bruce W, Professor

Basta, Sam, Professor

Blohm, Gunnar, Professor

Boehnke, Susan, Associate Professor

Brennan, Faith, Assistant Professor

Campbell, Robert L., Associate Professor

Capicciotti, Chantelle, Assistant Professor

Carver, L.F., Associate Professor

Chan, Edmond, Associate Professor

Colpitts, Che, Assistant Professor

Craig, Andrew, Professor

Davies, Peter L., Professor

De Felice, Fernanda, Associate Professor

Dick, Sarah, Assistant Professor

Domnik, Nicolle, Assistant Professor

Duan, Qingling, Associate Professor

Dumont, Eric C, Associate Professor

Dunham-Snary, Kimberly, Assistant Professor

Ferguson, Alastair V., Professor

Gallivan, Jason, Associate Professor

Gee, Katrina, Professor

Ghasemlou, Nader, Associate Professor

Graham, Charles H., Professor

Hindmarch, Charlie, Assistant Professor

Jia, Zongchao, Professor

Jones, Glenville, Professor

Kan, Frederick W.K., Professor

Kaufmann, Eva, Assistant Professor

Kawaja, Michael D., Professor

Koti, Madhuri, Associate Professor

Lomax, Alan, Professor

MacKenzie, Leslie W., Associate Professor

Magoski, Neil S., Professor

Maurice, Donald H., Professor

Mueller, Christopher R., Professor

Mulder, Jeanne, Assistant Professor

Munoz, Douglas P., Professor

Oby, Emily, Assistant Professor

Ormiston, Mark, Associate Professor

Ozolins, Terence, Associate Professor

Pang, Stephen C., Professor

Pare, Martin, Professor

Petkovich, P. Martin, Professor

Postovit, Lynne-Marie, Professor and Department Head

Reynolds, James N., Professor

Scott, Stephen H., Professor

Simpson, Amber, Associate Professor

Smith, Steven P., Professor

Stroman, Patrick , Professor

Szewczuk, Myron R., Professor

Talbot, Sebastien, Associate Professor

Tayade, Chandrakant , Professor

Ward, Christopher A., Associate Professor

Winn, Louise M., Professor

Zhang, Shetuan, Professor