Fetal Brain Injury after Prenatal Alcohol Exposure: The major focus of Dr. Reynolds’ research is on the effects of prenatal alcohol exposure on the developing brain and the resulting cognitive, behavioural and socio-emotional deficits that may occur in children. Dr. Reynolds has been the Principal Investigator for numerous grants awarded by the Canadian Institutes of Health Research for both basic and clinical studies on Fetal Alcohol Spectrum Disorder (FASD). Dr. Reynolds’ lab was the first to publish the results of studies describing deficits in saccadic eye movement control in children with FASD, and this continues to be a major focus of the research program. Dr. Reynolds is the Program Lead for the FASD Research Program in the Kids Brain Health Network, a national Network of Centres of Excellence dedicated to the study of neurodevelopmental disorders in children, and he also serves as the Chief Scientific Officer for the Network.
Fetal Alcohol Spectrum Disorders
Cognitive and Behavioural Deficits in Children with FASD
Eye movement control is a powerful tool for assessing various aspects of brain function, including sensory-motor control and cognitive flexibility. Our studies have demonstrated that behavioural deficits in eye movement control can be measured in children with FASD. Future studies will be aimed at developing eye movement tasks and other novel tools that can be used to assess brain function in children with FASD and other neurodevelopmental disorders.
Lussier A.A, A.M. Morin, J.L. MacIsaac, J. Salmon, J. Weinberg, J.N. Reynolds, P. Pavlidis, A.E. Chudley, M.S. Kobor. DNA methylation as a predictor of fetal alcohol spectrum disorder, Clin. Epigenetics 2018 Jan 12;10:5. doi: 10.1186/s13148-018-0439-6.
Paolozza, A., S. Treit, C. Beaulieu, J.N. Reynolds. Diffusion Tensor Imaging of White Matter and Correlates to Eye Movement Control and Psychometric Testing in Children with Prenatal Alcohol Exposure, Hum. Brain. Mapp. (2017) 38: 444-456.
Portales‑Casamar, E., A.A. Lussier, M.J. Jones, J.L. MacIsaac, R.D. Edgar, S.M. Mah, A. Barhdadi, S. Provost, L.P. Lemieux‑Perreault, M.S. Cynader, A.E. Chudley, M.P. Dubé, J.N. Reynolds, P. Pavlidis, M.S. Kobor. DNA methylation signature of human fetal alcohol spectrum disorder, Epigenetics & Chromatin (2016) 9:25.
Bell, E., G. Andrew, N. Di Pietro, A.E. Chudley, J.N. Reynolds, E. Racine. It’s a shame! Stigma against fetal alcohol spectrum disorder: Examining the ethical implications for public health practices and policies, Pub. Health Ethics, 9 (2016) 65-77.
Paolozza, A., S. Treit, C. Beaulieu, J.N. Reynolds. Response Inhibition Deficits in Children with Fetal Alcohol Spectrum Disorder: Relationship between Diffusion Tensor Imaging of the Corpus Callosum and Eye Movement Control. Neuroimage Clin. 2014, Jun 4;5:53-61. doi: 10.1016/j.nicl.2014.05.019. eCollection 2014.
Paolozza, A., C. Rasmussen, J. Pei, A. Hanlon-Dearman, S.M. Nikkel, G. Andrew, A. McFarlane, D. Samdup, J.N. Reynolds, Deficits in response inhibition correlate with oculomotor control in children with Fetal Alcohol Spectrum Disorder and Prenatal Alcohol Exposure, Behav. Brain Res. 259 (2014) 97-105.
Tseng, P.-H., I.G.M. Cameron, G. Pari, J.N. Reynolds, D.P. Munoz, and L. Itti. High-throughput classification of clinical populations from natural viewing eye movements, J. Neurol. 260 (2013) 275-284.
Bell, S.H., B. Stade, J.N. Reynolds, C. Rasmussen, G. Andrew, P.A. Huang and P.L. Carlen. The remarkably high prevalence of epilepsy and seizure history in fetal alcohol spectrum disorders, Alcohol. Clin. Exp. Res. 34 (2010) 1084-1089.
Green, C.R., A.M. Mihic, D.C. Brien, I.T. Armstrong, S.M. Nikkel, B.C. Stade, C. Rasmussen, D.P. Munoz and J.N. Reynolds. Oculomotor deficits in children with fetal alcohol spectrum disorders assessed using a mobile laboratory. Eur. J. Neurosci. 29 (2009) 1302-1309.
Green, C.R., A.M. Mihic, S.M. Nikkel, B.C. Stade, C. Rasmussen, D.P. Munoz and J.N. Reynolds. Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB), J. Child Psychol. Psychiatry 50 (2009) 688-697.