Skip to main content
Myron R. Szewczuk PhD
 Myron R. Szewczuk
Position(s)
Professor
Contact Info
Botterell Hall, Room 828
613-770-6403

Faculty Bio

  • B.Sc. (Hons.) 1971 - University of Guelph; Physical chemistry

  • MSc 1972 - University of Guelph; Biochemistry and thermodynmics of protein-protein interactions. Supervisor - Dr. Rattray

  • PhD  1974- University of Windsor; Biology and immunochemistry. Supervisor - Dr. T.K. Mukkur

  • Killiam Post-doctoral Research Scholar - Cornell University Medical College, New York City, U.S.A. Cellular immunology, with Dr. Greg Siskind (01/1975 - 05/1977).

  • NIH Post-doctoral Research Scholar - Cornell University Medical College, New York City, U.S.A. Cellular immunology, with Dr. Greg Siskind (05/1977 - 06/1978).

  • Research Associate - Cornell University Medical College, New York City, U.S.A. Aging of the immune system, with Drs. Greg Siskind and Marc Weksler (09/1975 - 06/1978).

  • Assistant Professor - Department of Pathology and Host Resistance, McMaster University, Hamilton, Ontario (07/1978 - 06/1981)
  • Associate Professor - Department of Microbiology & Immunology, Queen's University, Kingston, Ontario (07/1981 - 06/1987)
  • Associate Professor - Department of Medicine, Queen's University, Kingston, Ontario (08/1988 - present)
  • Full Professor - Department of Micriobiology& Immunology, Queen's University, Kingston, Ontario (07/1987 - 06/2011)
  • Full Professor - Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario (07/2011 - present)

Research interests:

1.)  Alternate therapeutic treatment of cancer. 
2.)  The role of glycosylation in the activation of neurotrophin Trk, EGFR, insulin and TOLL-like receptors. 
3.)  Molecular basis of Neu1 sialidase underlying TOLL-like receptor activation in pathophysiology of infections and inflammation. 
4.)  N-Acylated Hexosamines as Nutraceuticals: From Shellfish to Algae to Mammalian Bone and Joint Health. 
5.) 
 Trypanosome trans-sialidase for neuronal differentiation and neuroprotection from apoptosis

1.  Biased G protein-coupled receptors agonism 
2.  Insulin receptor in diseases
3.  Medicinal Marijuana
4. Alternate therapeutic approach in the treatment of human cancer
5. The role of glycosylation in receptor activation
6. Molecular basis of Neu1 sialidase underlying TOLL-like receptor activation in pathophysiology of infections and inflammation
7. N-Acylated Hexosamines as Nutraceuticals: From Shellfish to Algae to Mammalian Bone and Joint Health
8. Trypanosome trans-sialidase for neuronal differentiation and neuroprotection from apoptosis

Details of Research Interests:

(A) Cancer Research:
The cancer research initiated and funded by a private-sector donor was focused to evaluate an alternate therapeutic approach in the treatment of human pancreatic cancer. This approach is based on our reports identifying the key players involved in ligand-binding and receptor activation to a novel receptor-signaling platform and its targeted translation in human disease. The cancer research identified for the first time that Neu1 sialidase may be an important cancer-targeting enzyme which acts at the receptor level signaling platform on the cell surface to modulate a number of glycosylated receptors such as epidermal growth factor, nerve growth factor TrkA, insulin and TOLL-like receptors, all of which are known to play major roles in cancer. We have identified an alternate treatment strategy being in the form of a horizontal approach, of which several important cancer growth factor receptor signaling platforms, oncogenic pathways, cancer cell survival in acquired chemo-resistance and macrophage-mediated tumor progression are targeted with promising therapeutic intent. International PCT/CA2011/050690 patent filing November 04, 2011 

(B) Inflammation
The mammalian Toll-like receptors (TLRs) are one of the families of sensor receptors that recognize pathogen-associated molecular patterns (PAMPs). Not only are TLRs crucial sensors of microbial (e.g., viruses, bacteria and parasite) infections for innate immune cells, they also play an important role in the pathophysiology of infectious, inflammatory and  autoimmune diseases. Thus, the intensity and duration of TLR responses against infections and inflammatory diseases must be tightly controlled.  Although the signaling pathways of TLR sensors are well characterized, the parameters controlling interactions between the sensors and their ligands still remain poorly defined. We have recently identified a novel mechanism of TLR activation by its natural ligand, which has not been previously observed (Amith et.al. 2009 Glycoconj J). It suggests that ligand-induced TLR activation is tightly controlled by Neu1 sialidase activation. Our data indicate that Neu1 sialidase is already in complex with TLR-2, -3 and -4 receptors, and is induced upon ligand binding to either receptor.  Activated Neu1 sialidase  then hydrolyzes  sialyl a-2,3-linked β-galactosyl residues distant from ligand binding to remove steric hinderance to TLR-4 dimerization, MyD88/TLR4 complex recruitment (Amith et.al. 2009 Cell Signaling), NFkB activation and pro-inflammatory cell responses (Amith et.al. 2009 Glycoconj J).  We know that neuraminidase inhibitor Tamiflu (oseltamivir phosphate) blocks TLR ligand induced NFkB activation, nitric oxide (NO) production and pro-inflammatory cytokines (Amith et.al. 2009 Glycoconj J). We have reported to date that TLR ligand binding induces a receptor conformational change to mediate GPCR-signaling via membrane Gαi-proteins and matrix metalloproteinase-9 (MMP-9) to activate Neu1. In addition, we have identified the key players involved in the activation of nucleic acid sensing intracellular TLR-7 and -9 receptors against imiquimod and CpG oligodeoxynucleotide (ODN), respectively. It discloses a striking identical signaling paradigm as described for the cell-surface TLRs and for receptor tyrosine kinases such as Trks, epidermal growth factor and insulin.   Here, Neu1 sialidase and matrix metalloproteinase-9 (MMP9) cross-talk in alliance with G-protein coupled receptor (GPCR) neuromedin-B tethered to TLR-7 and -9 receptors at the ectodomain forms a novel molecular organizational GPCR signaling platform that is essential for ligand activation of the TLRs and cellular signaling.  These findings radically redefine the current dogma(s) governing the essential activating molecules tethered to nucleic acid sensing TLRs as well as to cell surface sensing TLRs, which may provide pioneering molecular targeting approaches to disease intervention strategies.

(C) Insulin receptor signaling
We have uncovered  a novel Neu1 and matrix metalloproteinase-9 (MMP-9) cross-talk in alliance with neuromedin B G-protein coupled receptor (GPCR), which is essential for insulin-induced IR activation and cellular signaling. Neu1, MMP-9 and neuromedin B GPCR form a complex with IRβ subunit on the cell surface.  Our findings identify a novel insulin receptor-signaling platformthat is critically essential for insulin-induced IRβ tyrosine kinase activation and cellular signaling. 

Selected Publications

2019

Manpreet Sambi1, Leila Bagheri1,2 and Myron R Szewczuk1. Current Challenges in Cancer Immunotherapy: Multimodal
Approaches to Improve Efficacy and Patient Response Rates. 2019 Journal of Oncology, Volume 2019, Article ID 4508794, 12 pages, https://doi.org/10.1155/2019/4508794 (Open Special Issue-Immunotherapy), (Impact factor: 4.528; indexed PubMed), Submitted for publication October 14, 2018, peer-reviewed, 1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Present address: Postdoctoral Fellow, Research Laboratories in Sciences, Applied to Food, Canadian Irradiation Center, Universite du Quebec, INRS-Institue Armand-Frappier, 531, boul. des Prairies, Laval, QC, H7V 1B7, Canada.   http://scholar.google.com/citations?user=CCG7638AAAAJ&hl=en&oi=ao
 

Iryna Liauchonak1,4, Bessi Qorri2,4, Fady Dawoud1,,Yatin Riat1,3,4, and Myron R. Szewczuk2,* Non-nutritive Sweeteners and their Implications on the Development of Metabolic Syndrome.  Nutrients 2019, 11, 644. http://dx.doi.org/10.3390/nu11030644  (impact factor 4.6, indexed PubMed). Received: 28 February 2019; Accepted: 13 March 2019 after extensive peer-review; Published:16 March 2019.  1Graduate Diploma and Professional Master in Medical Sciences, Postgraduate Medical Education, School of Medicine, Queen’s University, Kingston, ON, Canada; 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 3Present address: Emergency Medicine, Resident Physician, Brooklyn Hospital Centre, 121 DeKalb Avenue, Brooklyn, N.Y. 11201, USA. 4Contributing first authorship

Justin Jain1,3, Bessi Qorri2, 3 and Myron R. Szewczuk1,2,*. The Crucial Role of Primary Care Providers in the Long-term
follow up of Adult Survivors of Childhood Cancer. 2019 Cancer Management and Research, in press (impact factor 3.702, indexed PubMed). submitted for publication December 09, 2018, under peer-review, accepted for publication February 02, 2019. 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 1Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 3Contributing first authorship

2018

Bessi Qorri1, Regina-Veronicka Kalaydina1, Aleksandra Velickovic1, Yekaterina Kaplya1, Alexandria Decarlo2 and Myron R. Szewczuk1,* Agonist-biased signaling via matrix metalloproteinase-9 promotes extracellular matrix remodeling. Cells 2018, 7, 117; http://dx.doi.org/10.3390/cells7090117 (impact factor 4.829);  full-text archived in PubMed Central. 1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Department of Biology, Biosciences Complex, Queen’s University, Kingston, ON, Canada K7L 3N6. *corresponding author

Regina-Veronicka Kalaydina1,4, Komal Bajwa2,4, Bessi Qorri1,4, Alexandria Decarlo3, and Myron R. Szewczuk1,* Recent advances in “smart” delivery systems for extended drug release in cancer therapy. International Journal of Nanomedicine 2018:13 4727–4745, extensive peer-reviewed, indexed in PubMed Central  (impact factor: 5.008)DOI https://doi.org/10.2147/IJN.S168053.  1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 2Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 3Department of Biology, Queen’s University, Kingston, ON, Canada; 4Contributing first authorship
 

Xia Li1,6 & Manpreet Sambi2,6, Alexandria DeCarlo3, Sergey V Burov4, Roman Akasov5, Elena Markvicheva5, Cecile Malardier-Jugroot1,* and Myron R Szewczuk2,* Functionalized folic acid-conjugated amphiphilic alternating copolymer actively targets 3D multicellular tumor spheroids and delivers the hydrophobic drug to the inner core. Nanomaterials 2018, 8, 588; doi:10.3390/nano8080588,  extensive peer-reviewed, indexed in PubMed Central (5-Year Impact Factor: 3.811). 1Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada; 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 3Department of Biology, Queen’s University, Kingston, ON, Canada; 4Synthesis of Peptides and Polymer Microspheres Laboratory, Institute of Macromolecular Compounds, Russian Academy of Sciences, St Petersburg, Russia; 5Department of Biomaterials and Biotechnologies, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 6Contributing first authors, *corresponding authors. 

Iryna Liauchonak MD 1,3, Fady Dawoud MBBCh 1,3, Yatin Riat MD 1,3, Bessi Qorri BSc 2,3, Manpreet Sambi MSc 2,3, Justin Jain MD 1, Regina-Veronicka Kalaydina BSc 2, Nicole Mendonza 2, Komal Bajwa MBBS 1, and Myron R. Szewczuk PhD 2,*   Biased G-protein coupled receptor agonism bridges the gap between the insulin receptor and metabolic syndrome. Int. J. Mol. Sci. 201819, 575.  indexed in PubMed Central PMID:29462993 (Impact factor: 3.2) Received: 1 February 2018 / Revised: 11 February 2018 / Accepted: 15 February 2018 / Published: 17 February 2018. 1Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada; 2Department of Biomedical and Molecular Science, Queen’s University, Kingston ON, Canada;  3Contributing first authorship.   https://doi:10.3390/ijms19020575

Kurt Wood1, Myron R. Szewczuk2, Dérick Rousseau3 and Ronald J. Neufeld1. Oseltamivir phosphate released from injectable Pickering emulsions over extended term disables human pancreatic cancer cell survival. Oncotarget 2018, Vol. 9, (No. 16), pp: 12754-12768  (impact factor 5.168) peer-reviewed. Received: October 06, 2017 Accepted: January 20, 2018 Published: January 29, 2018.  1Chemical Engineering, Queen's University. 3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada, M5B 2K3. https://doi.org/10.18632/oncotarget.24339
 

Fiona Haxho, Sabah Haq and Myron R. Szewczuk. Biased G protein-coupled receptor agonism mediates Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of insulin receptor signaling. 2018 Cellular Signalling 43, 71-84 (impact factor 4.2). Received 20 July 2017; Received in revised form 26 November 2017; Accepted 21 December 2017. https://doi.org/10.1016/j.cellsig.2017.12.006

Yara Mouhamed1,3, Andrey Vishnyakov1,3, Bessi Qorri2,3, Manpreet Sambi2,3, Signy Frank1, Catherine Nowierski1, Anmol Lamba1, Umrao Bhatti1, and Myron R Szewczuk2,*. Therapeutic Potential of Medicinal Marijuana: An Educational Primer for Healthcare Professionals. 2018 Drug, Healthcare and Patient Safety 10: 45–66, indexed in PubMed Central PMID:29928146,  submitted 16/Jan/2018, extensive peer-review, accepted for publication March 9, 20181Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University. 2Department of Biomedical and Molecular Sciences, Queen’s University. 3Contributing first authorship.  https://www.dovepress.com/therapeutic-potential-of-medicinal-marijuana-an-educational-primer-for-peer-reviewed-article-DHPS

2017

Myron R Szewczuk. Biased G protein-coupled receptor agonism and mammalian neuraminidase 1-mediated glycosylated receptor signaling platform. J Glycobiol 2017, 6:2(Suppl). Department of Biomedical and Molecular Sciences, Queen’s University         DOI: 10.4172/2168-958X-C1-008

Manpreet Sambi1,3, Bessi Qorri1,3, S.M. Signy Frank2, Yara Mouhamed2, Regina-Veronicka Kalaydina1, Nicole Mendonza1, and Myron R. Szewczuk1*. Novel Use of Peptides to Facilitate the Formation of 3D Multicellular Tumor Spheroids. 2017 Curr Top Pept Protein Res 18, 25-341Department of Biomedical and Molecular Sciences, Queen’s University. 2Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen’s University. 3Contributing first authorship. 
http://www.researchtrends.net/tia/article_pdf.asp?in=0&vn=18&tid=26&aid…

Bessi Qorri1, Manpreet Sambi1, and Myron R Szewczuk. Invited Book Editors. Current Applications for Overcoming Resistance to Targeted Therapies. Springer Publisher, New York, NY. in preparation November 17, 2017.  1Contributing first authorship.

Regina-Veronicka Kalaydina1,2 & Bessi Qorri1,2, Myron R. Szewczuk1*.  Preventing Negative Shifts in Gut Microbiota with Cannabis Therapy: Implications for Colorectal Cancer. 2017 Adv Res Gastroentero Hepatol  2017; 7(3): 555712. DOI: 10.19080/ARGH.2017.07.555712. submitted October 3, 2017 under peer-review, published October 12, 2017 as it stands in current form. 2contributing first authors.

Sabah Haq1,2,3, Manpreet Sambi1,3, Bessi Qorri1,3, Nicole Mendonza1,3 & Myron R. Szewczuk1*. Aberrant Sialic Acid Expression and its Role in Regulating Metastasis in Colorectal Cancer. 2017 Adv Res Gastroentero Hepatol volume 7, issue 2.  submitted September 13, 2017 under peer-review, accepted for publication September 15, 2017 as it stands in current form. 3contributing first authors.
DOI: 10.19080/ARGH.2017.07.555707

Bessi Qorri1,2 & Manpreet Sambi1,2, Myron R. Szewczuk1*. Gut Microbiota and its Implications on the Progression of Gastrointestinal Cancer. Adv Res Gastroentero Hepatol 6(5): ARGH.MS.ID.555696 (2017). . submission: August 11, 2017; published: August 15, 2017 as it stands in current form.  2contributing first authors. 
DOI:10.19080/ARGH.2017.06.555696

Fiona Haxho, Sabah Haq and Myron R. Szewczuk. Biased G protein-coupled receptor agonism mediates Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of insulin receptor signaling. 2017 Cellular Signalling  (impact factor 4.2) in press. Received 20 July 2017; Received in revised form 26 November 2017; Accepted 21 December 2017. https://doi.org/10.1016/j.cellsig.2017.12.006

Manpreet Sambi1,2 & Bessi Qorri1,2Cecile Malardier-Jugroot3, and Myron R. Szewczuk1*. Advancements in Polymer Science: ‘Smart’ Drug Delivery Systems for the Treatment of Cancer. 2017 MOJ Poly Sci 1(3): 00016. 3 Head, Department of Chemistry and Chemical Engineering, Sawyer Mod 5, Rm 5512, Royal Military College of Canada, PO Box 17000, Station Forces Kingston, ON K7K 7B4, Canada. 2contributing first authors. DOI: 10.15406/mojps.2017.01.00016

Kurt Wood1, Myron R. Szewczuk2, Dérick Rousseau3 and Ronald J. Neufeld1. Oseltamivir phosphate released from injectable Pickering emulsions over extended term disables human pancreatic cancer cell survival. Oncotarget, 2018, Vol. 9, (No. 16), pp: 12754-12768 (impact factor 6) peer-reviewed, Received: October 06, 2017 Accepted: January 20, 2018 Published: January 29, 2018. 1Chemical Engineering, Queen's University. 3Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada, M5B 2K3. https://doi.org/10.18632/oncotarget.24339

Manpreet Sambi1 & Bessi Qorri1, William Harless2 and Myron R Szewczuk. Therapeutic options for Metastatic Breast Cancer. Springer Book ‘Breast Cancer Metastasis and Drug Resistance’ – 2nd Volume, accepted for publication in preparation for July 31, 2017 due date. 1contributing first authors, 2ENCYT Technologies, Inc. Membertou, NS, Canada.

Manpreet Sambi1,2 & Fiona Haxho1,2, Bessi Qorri1,2, William Harless3*, Myron R. Szewczuk1*. Pancreatic Adenocarcinoma: Current Therapies and Challenges. 2017 Adv Res Gastroentero Hepatol 4(4): ARGH.MS.ID.555643 (2017) 001, submitted April 15, 2017, accepted for publication April 18, 2017 as it stands in current form. 2contributing first authors. 3ENCYT Technologies, Inc. Membertou, NS, Canada.  https://juniperpublishers.com/argh/pdf/ARGH.MS.ID.555643.pdf

Stephanie N. Allison Logan1,2, Amanda J. Brissenden1, Myron R. Szewczuk3, and Ronald J. Neufeld1. Combinatorial and sequential delivery of gemcitabine and oseltamivir phosphate from implantable poly (lactic-co-glycolic acid) cylinders disables human pancreatic cancer cell survival. Drug Design, Development and Therapy 2017 Volume 2017:11 Pages 2239—2250, submitted March 24, 2017, published 31 July 2017.  1Chemical Engineering, Queen's University. 2Polymer Science Group, Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria 3010, Australia.
DOI https://doi.org/10.2147/DDDT.S137934 

Fiona Haxho1,  Manpreet Sambi1  &  Bessi  Qorri1, William Harless, Myron R. Szewczuk. Current clinical challenges and emerging multi-modal approaches for the treatment of pancreatic cancer.  Clin Oncol. 2017; 2: 1296,  submitted March 11, 2017, accepted for publication April 13, 2017 as it stands in current form.  1- contributing first authors.

Sabah Haq, Fiona Haxho, Vanessa Samuel, Roman Akasov, Maria Leko, Sergey V. Burov, Elena Markvicheva and Myron R. Szewczuk.Sialylation facilitates self-assembly of 3D multicellular prostaspheres using cyclo-RGDfK(TPP) peptide. OncoTargets and Therapy 2017:10 2427–2447accepted March 08, 2017as it stands in current form. 
http://www.ncbi.nlm.nih.gov/pubmed/28496342

Manpreet Sambi, Sabah Haq, Vanessa Samuel, Bessi Qorri, Fiona Haxho, Kelli Hill, William Harless and Myron R. Szewczuk.Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity. Breast Cancer - Targets and Therapy 2017:9 1–9. Received 23rd December 2016Accepted 15th February 2017 as it stands in current form.   DOIhttps://doi.org/10.2147/BCTT.S130838

Manpreet Sambi and Myron R. Szewczuk. KRAS mutations: efficacy and sensitivity of early predictive screening of cancer progression require other gene mutations in addition to KRAS. Translational Cancer Research 2017;6(Suppl 1) S15-S17. Received 8th December 2016, Accepted 11th December 2016 as it stands in current form.
DOI: http://dx.doi.org/10.21037/tcr.2017.01.05

2016
Xia Li, Myron R. Szewczuk and Cecile Malardier-Jugroot.
Folic acid conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform. Drug Design, Development and Therapy 2016:10 1–10.DOIhttps://doi.org/10.2147/DDDT.S123386

Roman Akasov, Sabah Haq, Fiona Haxho, Vanessa Samuel, Sergey V. Burov, Elena Markvicheva, Ronald J. Neufeld, and Myron R. Szewczuk. Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD peptide induced self-assembly. 2016 Oncotarget 2016, Vol. 7, No.40 66119-661342016. (impact factor 6.4) Received: June 21, 2016 Accepted: August 25, 2016. 
DOI:10.18632/oncotarget.11868

Fiona Haxho, Ronald J. Neufeld and Myron R. Szewczuk.Neuraminidase-1: A novel therapeutic target in multistage
tumorigenesis.  Oncotarget 2016, Vol. 7, No. 26, pages 40860-40881. (impact factor 6.4) Received: March 01, 2016 Accepted: March 18, 2016 Published: March 27, 2016
DOI: 10.18632/oncotarget.8396

Vitaliy Kapishon, Stephanie Allison, Ralph A. Whitney, Michael F. Cunningham, Myron R. Szewczuk and Ronald J. Neufeld. Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform. Biomater. Sci., 2016, 4, 51. Received 9th November 2015, Accepted 11th January 2016
DOI: 10.1039/c5bm00519a

2015
Michael Hrynyk, Jordon P. Ellis, Fiona Haxho, Stephanie Allison, Joseph A.M. Steele­, Samar Abdulkhalek, Ronald J. Neufeld and Myron Szewczuk.Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma. Drug Design, Development and Therapy 2015:9 4573-4586 . Received 9 June 2015, Accepted 2 July 2015, Published 10 August 2015. Open access - Metrics views 658 since 10/08/2015 to 26/08/2015.

DOI http://dx.doi.org/10.2147/DDDT.S90170

Schammim Ray Amith, Samar Abdulkhalek and Myron R. Szewczuk. Role of Glycosylation in TOLL-like Receptor Activation and Pro-inflammatory Responses. Textbook, Glycobiology and Diseases: Chapter 9, pages 165-185 © 2016 by Taylor & Francis Group, LLC

2014
Fiona Haxho, Stephanie Allison, Farah Alghamdi, Lacey Brodhagen, Victoria EL Kuta, Samar Abdulkhalek, Ronald J Neufeld, and Myron R Szewczuk
. Oseltamivir phosphate monotherapy ablates tumor neovascularization, growth, and metastasis in mouse model of human triple-negative breast adenocarcinoma. Breast Cancer: Targets and Therapy 2014: 6 191-203. Received 23 September 2014, Accepted 10 October 2014, Published 9 December 2014. 
DOI http://dx.doi.org/10.2147/BCTT.S74663

Fiona Haxho, Farah Alghamdi, Ronald J Neufeld and Myron R Szewczuk. Novel Insulin Receptor-Signaling Platform. Int J Diabetes Clin Res; Review Article 2014 IJDCR-1-005 (Vol 1, issue 1). Received: October 09, 2014: Accepted: October 27, 2014: Published: October 30, 2014; 
DOI: https://www.clinmedjournals.org/articles/ijdcr/ijdcr-1-005.pdf 

Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O’Shea, Ronald J Neufeld and Myron R Szewczuk. Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma. Clinical and Translational Medicine 2014, 3:28. ©  Abdulkhalek et al.; licensee Springer. 2014. Received: 21 June 2014, Accepted: 24 July 2014, Published: 23 September 2014. Article accesses: 3129.  DOI: 10.1186/s40169-014-0028-z

Farah Alghamdi, Merry Guo, Samar Abdulkhalek, Nicola Crawford, Schammim Ray Amith and Myron R. Szewczuk. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. Cellular Signalling 26 (2014) 1355–1368, (open accesssubmitted Feb08, 2014 accepted Feb23, 2014 as it stands (Impact factor: 4.3).
DOI: http://dx.doi.org/10.1016/j.cellsig.2014.02.015 

O’Shea LK, Abdulkhalek S, Allison S, Neufeld RJand Szewczuk MR.Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance. OncoTargets and Therapy 2014:7 117–134. Published 14 January 2014 (Open access: Total articles views: 1219 to March 8, 2014
DOI: http://dx.doi.org/10.2147/OTT.S55344

2013 -2004
Samar Abdulkhalek
and Myron R. Szewczuk. Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses. Cellular Signalling, Volume(s) 25, 01-Jul-2013, Pages 2093-2105Open access: Total article views: 1060 (July 2013 to December 2013) 
DOI:
http://dx.doi.org/10.1016/j.cellsig.2013.06.010

Alanna M. Gilmour, Samar Abdulkhalek, Timothy S.W. Cheng, Farah Alghamdi, Preethi Jayanth, Leah K. O’Shea, Olivia Geen, Luis A. Arvizu, and Myron R.    Szewczuk.A novel epidermal growth factor receptor-signaling platform and its  targeted translation in pancreatic cancer. Cellular Signalling 25, Issue 12, December 2013, Pages 2587–2603 (Received 6 August 2013; Accepted 23 August 2013; open access: total metric article views: 1521 as of September 2013-December 2013) 
DOI:
http://dx.doi.org/10.1016/j.cellsig.2013.08.008

Samar AbdulkhalekMichael Hrynyk and Myron R Szewczuk. Review - A novel GPCR receptor signalling platform and its targeted translation in human disease.     Research and Reports in Biochemistry. Received 03Oct2012; accepted 24Oct2012 peer-reviewed; 07Jan2013 Open access; Total metric article views: 3052 (as of 07Jan 2013)

http://www.dovepress.com/a-novel-g-protein-coupled-receptor-signaling-platform-     and-its-targeted-peer-reviewed-article-RRBC 

Vandana Gambhir, Christopher Yildiz, Rylend Mulder, Sarah Siddiqui, Christina Guzzo, Myron Szewczuk, Katrina Gee and Sameh Basta. The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated mycobacterium butyricum. Cellular Immunology Volume 280, Issue 1, November 2012, Pages 101–107http://dx.doi.org/10.1016/j.cellimm.2012.12.001

Samar Abdulkhalek, Merry Guo, Schammim Ray Amith, Preethi Jayanth, and Myron R. Szewczuk. G-Protein Coupled Receptor Agonists Mediate Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-Talk to Induce Transactivation of TOLL-Like Receptors and Cellular Signaling. Cellular Signaling 24 (2012) 2035–2042. DOI: 10.1016/j.cellsig.2012.06.016, submit Jun4, 2012 accepted June 25, 2012 as it stands (Impact factor 4.3)

Samar Abdulkhalekǂ,1, Schammim Ray Amithǂ,1, Susan L. Franchukǂ, Preethi Jayanthǂ,2, Merry Guoǂ, Trisha Finlayǂ,3, Alanna Gilmourǂ, Christina Guzzoǂ, Katrina Geeǂ, Rudi Beyaert§, and Myron R. Szewczuk. Neu1 sialidase and matrix   metalloproteinase-9 cross-talk is essential for TOLL-like receptor activation and cellular signaling. Journal of Biological Chemistry (2011) VOL. 286, NO. 42, pp. 36532–36549 JBC/2011/237578 (Impact factor 7.3)

Trisha M. FinlaySamar Abdulkhalek,  Alanna GilmourChristina GuzzoPreethi JayanthSchammim Ray Amith,  Katrina Gee,Rudi Beyaert, Myron R Szewczuk Thymoquinone-induced Neu4 Sialidase Activates NFκB in Macrophage Cells and Pro-inflammatory Cytokines In Vivo.  Glycoconj J, 27 583–600 (DOI: 10.1007/s10719-010-9302-5)(2010)(Impact factor 2.7)

Schammim Ray Amith,  Preethi Jayanth,  Trisha Finlay, Susan Franchuk,  Alanna Gilmour, Samar Abdulkhalek,  Myron R. Szewczuk. Detection of  Neu1 sialidase activity in regulating TOLL-like receptor activation. J. of Visualized Experiments (DOI:10.37912142) (2010)(This JoVE article has been viewed 12,630 times since Oct 01-2011)

Preethi Jayanth2, Schammim Ray Amith2, Katrina Gee2and Myron  R. Szewczuk. Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk is Essential for Neurotrophin Activation of Trk Receptors and Cellular Signaling. Cell Signal 22 1193-1205 (2010) (DOI: 10.1016/j.cellsig.2010.03.011) (Impact factor 4.3)

Trisha M. FinlayPreethi JayanthSchammim Ray AmithAlanna GilmourChristina GuzzoKatrina Gee, Rudi Beyaert, and Myron R Szewczuk. Thymoquinone from Nutraceutical Black Cumin Oil Activates  Neu4 Sialidase in Live Macrophage, Dendritic, and Normal and Type I Sialidosis Human Fibroblast Cells via GPCR Gαi proteins and Matrix Metalloproteinase-9. Glycoconj. J. 27 329–348 (2010) DOI: 10.1007/s10719-010-9281-6 (Impact factor 2.7)

Volkan Seyrantepe, Alexandre Iannello, Feng Liang, Evgeny Kanshin, Preethi Jayanth, Suzanne Samarani, Myron R. Szewczuk, Ali Ahmad, and Alexey V. Pshezhetsky. Regulation of Phagocytosis in Macrophages by Neuraminidase 1. Journal of Biological     Chemistry (2010) 285(1): 206-215(Impact factor 7.3)

Schammim Ray Amith, Preethi Jayanth, Susan Franchuk, Trisha Finlay, Volkan Seyrantepe, Rudi Beyaert, Alexey V. Pshezhetsky and Myron R. Szewczuk. Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling. Cellular Signalling (2010) 22 314–324. (Impact factor 4.3) (citation index: 26)

 Schammim Ray AmithPreethi JayanthSusan FranchukSarah SiddiquiVolkan Seyrantepe, Katrina Gee,Sameh Basta, Rudi Beyaert, Alexey V. Pshezhetsky and Myron  R. Szewczuk. Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase. Glycoconj J (2009) 26:1197-1212 (Impact factor 2.7)

Alicja Woronowicz, Schammim Ray Amith, Vanessa, W Davis, Preethi Jayanth, Kristof De Vusser, Wouter Laroy, Roland Contreras, Susan O Meakin, and Myron R Szewczuk. Glycobiology vol. 17 no. 7 pp. 725–734, 2007 (doi:10.1093/glycob/cwm034)

Alicja Woronowicz, Schammim R. Amith, Kristof De Vusser, Wouter Laroy, Roland Contreras, Sameh Basta, and Myron R. Szewczuk. Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.  Glycobiology vol. 17 no. 1 pp. 10–24, 2007 (doi:10.1093/glycob/cwl049)

Alicja Woronowicz, Kristof De Vusser, Wouter Laroy,  Roland Contreras, Susan O. Meakin, Gregory M. Ross, and Myron R. Szewczuk. Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation. Glycobiology vol. 14 no. 11 pp. 987–998, 2004 (doi:10.1093/glycob/cwh123)