Lab website: www.mitometablab.com
Academic Experience
2015-2020: CIHR and CVN Postdoctoral Fellow (Stephen Archer), Department of Medicine, Queen’s University
2009-2014: PhD in Molecular & Cellular Pathology (Scott Ballinger), Department of Pathology, University of Alabama at Birmingham
2006-2008: MPS in Forensic Science (Robert Shaler), Eberly College of Science, The Pennsylvania State University
2002-2006: B.Sc. (Hons.) in Applied Bio-Molecular Science (Carney Matheson), Faculty of Science & Environmental Studies, Lakehead University
Research Interests
My laboratory studies cardiovascular and cardiometabolic diseases. Using in vitro and in vivo preclinical models, we investigate the role of mitochondrial genetics and organelle structure in the aetiology and pathophysiology of these complex pathologies. Please visit the lab’s website for more information: www.mitometablab.com
Funding Support
- Canadian Institutes for Health Research
- New Frontiers Research Fund
- Canada Research Chairs
- Canada Foundation for Innovation
- Banting Research Foundation
Selected Publications
Shastry, AM, Dunham-Snary KJ. Metabolomics and mitochondrial dysfunction in cardiometabolic disease. Life Sci. 2023 Oct 1:122137. DOI: 10.1016/j.lfs.2023.122137. Online ahead of print.
Wilkinson MS, Dunham-Snary KJ. Blood-based bioenergetics: a liquid biopsy of mitochondrial dysfunction in disease. Trends Endocrinol Metab. 2023 Jul 4;S1043-2760(23)00115-7.
DOI: 10.1016/j.tem.2023.06.004.
Dunham-Snary KJ. The haplogroup gap: The ticking time bomb of cardiometabolic disease in developing nations. Open Access Government. 2023 Jan;20:142-143. DOI: 10.56367/OAG-037-10518
Mason E, Hindmarch CCT, Dunham-Snary KJ. Medium-chain acetyl Co-A dehydrogenase deficiency: pathogenesis, diagnosis, and treatment. Endocrinol Diabetes Metab. 2023 Jan;6(1):e385.
Dunham-Snary KJ, Surewaard BGJ, Mewburn JD, Lima PDA, Jones O, Al-Qazazi R, Martin AY, Bentley RET, Kubes P, Archer SL. Mitochondria in human neutrophils mediate killing of staphylococcus aureus. Redox Biol. 2022 Feb;49:102225.
Read A#, Bentley R#, Archer SL, Dunham-Snary KJ. Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol. 2021 Nov;47:102164.
Dunham-Snary KJ, Wu D, Sykes EA, Potus F, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL. Ndufs2, a core subunit of mitochondrial complex I, is essential for acute oxygen-sensing and hypoxic pulmonary vasoconstriction. Circ Res. 2019 Jun 7;124(12): 1727-1746.
Dunham-Snary KJ, Sandel MW, Sammy MJ, Westbrook DG, Xiao R, McMonigle RJ, Ratcliffe, WF, Penn A, Young ME, Ballinger SW. Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo. EBioMedicine. 2018 Oct;36:316-328.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LR, Mewburn JD, Parlow JL, Archer SL. Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine. Chest. 2017 Jan;151(1):181-192.
Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL. A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus. Pflugers Arch. 2016 Jan;468(1):43-58.
Dunham-Snary KJ, Ballinger SW. GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science. 2015 Sep 25;349(6255):1449-50.
Dunham-Snary KJ, Sandel MW, Westbrook DG, Ballinger SW. A method for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biol. 2014 Apr 18;2:656-60.
Dunham-Snary KJ, Ballinger SW. Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility. Free Radic Biol Med. 2013 Dec;65:1229-37.
Lab Members
The Dunham-Snary Lab (MitoMetabLab) is currently home to numerous undergraduate and graduate students with backgrounds in cellular and/or molecular biology, life sciences, and other medical and health-related fields. Please check back the lab’s website (www.mitometablab.com) for up-to-date information regarding available positions.