Brien | Biomedical and Molecular Sciences | School of Medicine

James F. Brien PhD

Position(s)

Emeritus Professor

Contact Info

Faculty Bio

Our research program is focused on ethanol (alcohol) teratogenicity/developmental toxicity (fetal alcohol syndrome/fetal alcohol spectrum disorders), with current emphasis on brain dysfunction and metabolic disturbances, and intervention strategies.

Research Interests

The research program in our laboratory focuses on the investigation of the mechanisms of therapeutic or toxic action of a broad spectrum of drugs. Currently, our laboratory is investigating the mechanisms of : alcohol teratogenicity/developmental toxicity (fetal alcohol syndrome/fetal alcohol spectrum disorders); action of nitrovasodilator drugs, nitric oxide and carbon monoxide on blood vessels; and amiodarone-induced pulmonary toxicity.

Selected Publications

196. G.E. Lash, B.E. McLaughlin, S.K. Macdonald-Goodfellow, G.N. Smith, J.F. Brien, G.S. Marks, K. Nakatsu, and C.H. Graham. Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta. Amer. J. Physiol., 284, H160-H167 (2003).

197. J.W. Card, W.J. Racz, J.F. Brien, and T.E. Massey. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J. Pharmacol. Exp. Ther., 304, 277-283 (2003).

198. M.L. Hard, U. Iqbal, J.F. Brien, and G. Koren. Binding of acetaldehyde to human and guinea pig placentae in vitro. Placenta, 24, 149-154 (2003).

199. S.D. Appleton, G.S. Marks, K. Nakatsu, J.F. Brien, G.N. Smith, C.H. Graham, and G.E. Lash. Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. Amer. J. Physiol., 284, H853-H858 (2003).

200. N.S. Butters, J.N. Reynolds, and J.F. Brien. Effects of chronic prenatal ethanol exposure on cGMP content and glutamate release in the hippocampus of the neonatal guinea pig. Neurotoxicol. Teratol., 25, 59-68 (2003).

201. B.E. McLaughlin, G.E. Lash, G.N. Smith, G.S. Marks, K. Nakatsu, C.H. Graham, and J.F. Brien. Heme oxygenase expression in selected regions of term human placenta. Exp. Biol. Med., 228, 564-567 (2003).

202. M.L. Byrnes, J.N. Reynolds, and J.F. Brien. Brain growth spurt-prenatal ethanol exposure and the guinea pig hippocampal glutamate signaling system. Neurotoxicol. Teratol., 25, 303-310 (2003).

203. T.S. Dettmer, A. Barnes, U. Iqbal, C.D.C. Bailey, J.N. Reynolds, J.F. Brien, and C.F. Valenzuela. Chronic prenatal ethanol exposure alters ionotropic glutamate receptor subunit protein levels in the adult guinea pig cerebral cortex. Alcoholism: Clin. Exp. Res., 27, 677-681 (2003).

204. T.N. McGoey, J.N. Reynolds, and J.F. Brien. Chronic prenatal ethanol exposure-induced decrease of guinea pig hippocampal CA1 pyramidal cell and cerebellar Purkinje cell density. Can. J. Physiol. Pharmacol., 81, 476-484 (2003).

205. R.K. Puri, J.N. Reynolds, and J.F. Brien. Effects of chronic prenatal ethanol exposure on NMDA receptor number and affinity for [3H]MK-801 in the cerebral cortex of the young postnatal and adult guinea-pig. Reprod. Fertil. Dev., 15, 207-214 (2003).

206. J.W. Card, W.J. Racz, J.F. Brien, S.B. Margolin, and T.E. Massey. Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity. Toxicol. Sci., 75, 169-180 (2003).

207. G.S. Marks, J.F. Brien, and K. Nakatsu. What role does the heme - heme oxygenase - carbon monoxide system play in vasoregulation? Amer. J. Physiol., 285, R522-R523 (2003).

208. S.D. Appleton, G.E. Lash, G.S. Marks, K. Nakatsu, J.F. Brien, G.N. Smith, and C.H. Graham. Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. Amer. J. Physiol., 285, R1453-R1460 (2003).

209. M.L. Hayward, A.E. Martin, J.F. Brien, H.C. Dringenberg, M.C. Olmstead, and J.N. Reynolds. Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig. J. Pharmacol. Exp. Ther., 308, 644-650 (2004).

210. C.D.C. Bailey, J.F. Brien, and J.N. Reynolds. Chronic prenatal ethanol exposure alters the proportion of GABAergic neurons in layers II/III of the adult guinea pig somatosensory cortex. Neurotoxicol. Teratol., 26, 59-63 (2004).

211. U. Iqbal, H.C. Dringenberg, J.F. Brien, and J.N. Reynolds. Chronic prenatal ethanol exposure alters hippocampal GABAA receptors and impairs spatial learning in the guinea pig. Behav. Brain Res., 150, 117-125 (2004).

212. A.A. Nava-Ocampo, Y. Velazquez-Armenta, J.F. Brien, and G. Koren. Elimination kinetics of ethanol in pregnant women. Reprod. Toxicol., 18, 613-617 (2004).

213. L. Bui, K. Rish, K. Jaronczyk, S. Bourque, B.E. McLaughlin, J.F. Brien, G.S. Marks, A. Smith, and K. Nakatsu. The source of heme for vascular heme oxygenase I: Heme uptake in rat aorta. Can. J. Physiol. Pharmacol., 82, 209-217 (2004).

214. K. Jaronczyk, L. Bui, J.M. Soong, B.E. McLaughlin, G.S. Marks, J.F. Brien, and K. Nakatsu. The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta. Can. J. Physiol. Pharmacol., 82, 218-224 (2004).

215. M.L. Byrnes, D.P. Richardson, J.F. Brien, J.N. Reynolds, and H.C. Dringenberg. Spatial acquisition in the Morris water maze and hippocampal long-term potentiation in the adult guinea pig following brain growth spurt-prenatal ethanol exposure. Neurotoxicol. Teratol., 26, 543-551 (2004).

216. J.Z. Vlahakis, R.T. Kinobe, R.J. Bowers, J.F. Brien, K. Nakatsu, and W.A. Szarek. Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. Bioorg. Med. Chem. Lett., 15, 1457-1461 (2005).

217. U. Iqbal, J.F. Brien, S. Banjanin, M.H. Andrews, S.G. Matthews, and J.N. Reynolds. Chronic prenatal ethanol exposure alters glucocorticoid signalling in the hippocampus of the postnatal guinea pig. J. Neuroendocrinol., 17, 600-608 (2005).

218. H. Ahmed, B.E. McLaughlin, J. Soong, G.S. Marks, J.F. Brien, and K. Nakatsu. The source of endogenous carbon monoxide formation in human placental chorionic villi. Cell. Mol. Biol., 51, 447-451 (2005).

219. C.R. Green, S.M. Kobus, Y. Ji, B.M. Bennett, J.N. Reynolds, and J.F. Brien. Chronic prenatal ethanol exposure increases apoptosis in the hippocampus of the term fetal guinea pig. Neurotoxicol. Teratol., 27, 871-881 (2005).

220. D.L. Caprara, J.F. Brien, U. Iqbal, J.N. Reynolds, J. Klein, and G. Koren. A guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair. Pediatric Res., 58, 1158-1163 (2005).

221. R.T. Kinobe, J.Z. Vlahakis, H.J. Vreman, D.K. Stevenson, J.F. Brien, W.A. Szarek, and K. Nakatsu. Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms. Br. J. Pharmacol., 147, 307-315 (2006).

222. U. Iqbal, S. Rikhy, H.C. Dringenberg, J.F. Brien, and J.N. Reynolds. Spatial learning deficits induced by chronic prenatal ethanol exposure can be overcome by non-spatial pretraining. Neurotoxicol. Teratol., 28, 333-341 (2006).

223. J.F. Brien, D. Chan, C.R. Green, U. Iqbal, J. Gareri, S.M. Kobus, B.E. McLaughlin, J. Klein, C. Rao, J.N. Reynolds, A.D. Bocking, and G. Koren. Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal guinea pig. Ther. Drug Monitor., 28, 345-350 (2006).

224. C.R. Green, L.T. Watts, S.M. Kobus, G.I. Henderson, J.N. Reynolds, and J.F. Brien. Effects of chronic prenatal ethanol exposure on mitochondrial glutathione and 8 prostaglandin F 2±_concentrations in the hippocampus of the perinatal guinea pig. Reprod. Fertil. Dev., in press (2006).

225. R.T. Kinobe, J. Vlahakis, J.M. Soong, W.A. Szarek, J.F. Brien, L.D. Longo, and K. Nakatsu. Heme oxygenase activity in fetal and adult sheep accllimatized to high altitude hypoxia. Can. J. Physiol. Pharmacol., in press (2006).

226. J.Z. Vlahakis, R.T. Kinobe, R.J. Bowers, J.F. Brien, K. Nakatsu, and W.A. Szarek. Imidazole-dioxolane compounds as heme oxygenase inhibitors with enhanced selectivity for HO-1. J. Med. Chem., in press (2006).

227. V. Kulaga, D. Caprara, U. Iqbal, B. Kapur, J. Klein, J. Reynolds,J. Brien, and G. Koren. Fatty acid ethyl esters (FAEE): Comparative accumulation in human and guinea pig hair as a biomarker for prenatal ethanol exposure. Alcohol Alcoholism, in press (2006).

228. R.T. Kinobe, R.A. Dercho, J.Z. Vlahakis, J.F. Brien, W.A. Szarek, and K. Nakatsu. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J. Pharmacol. Exp. Ther., in press (2006).

229. U. Iqbal, J.F. Brien, A. Kapoor, S.G. Matthews, and J.N. Reynolds. Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term fetal guinea pig. J. Neuroendocrinol., in press (2006).

Team

Faculty Bio

Research Interests

Selected Publications

Faculty